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BAN1481

BAN1481
  • Catalog: BAN1481
  • Gene/Protein: P17900
  • Product Description: Ganglioside GM2 activator/GM2A
Ganglioside GM2 activator/GM2A
Protein Specification
Description Recombinant Human Ganglioside GM2 activator is produced by our Mammalian expression system and the target gene encoding Ser32-Ile193 is expressed with a 6His tag at the C-terminus.
Alternate Names Ganglioside GM2 activator;Cerebroside sulfate activator protein;GM2-AP;Sphingolipid activator protein 3;SAP-3
Accession No. P17900
Amino Acid Range Ser32-Ile193
Tag C-6His
Species Human
Source Human cells
Background Ganglioside GM2 activator (GM2A) is a small glycolipid transport protein which acts as a substrate specific co-factor for the lysosomal enzyme β-hexosaminidase A (HEXB). HEXB together with GM2A, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. GM2A accommodate several single chain phospholipids and fatty acids, is a lipid transfer protein that stimulates the enzymatic processing of gangliosides, and also T-cell activation through lipid presentation. It extracts single GM2 molecules from membranes and presents them in soluble form to beta-hexosaminidase A for cleavage of N-acetyl-D-galactosamine and conversion to GM3.
Purity Greater than 95% as determined by reducing SDS-PAGE.
Product Form Lyophilized
Formulation Lyophilized from a 0.2 μm filtered solution of 20mM TrisHCl, 150mM NaCl, pH 7.5.
Entotoxin Levels Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test.
Reconstitution Dissolve the lyophilized protein in distilled water.
Storage Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7°C for 2-7 days.Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Shipping The product is shipped at ambient temperature.
Datasheet

Material Safety Data Sheet
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