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  • Gene/Protein: PROM1
  • Product Description: Immunotag™ CD133 Monoclonal Antibody
Price in reward points: 368

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Immunotag™ CD133 Monoclonal Antibody
Antibody Specification
Target Protein CD133
Clonality Monoclonal
Storage/Stability -20°C/1 year
Application IHC-p,FCM,ELISA
Recommended Dilution Immunohistochemistry: 1/200 - 1/1000. Flow cytometry: 1/200 - 1/400. ELISA: 1/10000. Not yet tested in other applications.
Concentration 1 mg/ml
Reactive Species Human
Host Species Mouse
Immunogen Synthesized peptide of human CD133.
Specificity CD133 Monoclonal Antibody detects endogenous levels of CD133 protein.
Purification Affinity purification
Form Ascitic fluid containing 0.03% sodium azide.
Gene Name PROM1
Accession No. O43490 O54990
Alternate Names PROM1; Prominin-1; Antigen AC133; Prominin-like protein 1; CD antigen CD133
Description prominin 1(PROM1) Homo sapiens This gene encodes a pentaspan transmembrane glycoprotein. The protein localizes to membrane protrusions and is often expressed on adult stem cells, where it is thought to function in maintaining stem cell properties by suppressing differentiation. Mutations in this gene have been shown to result in retinitis pigmentosa and Stargardt disease. Expression of this gene is also associated with several types of cancer. This gene is expressed from at least five alternative promoters that are expressed in a tissue-dependent manner. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009],
Protein Expression Aorta,Colon,Epithelium,Fetal liver,Retinoblastoma,
Subcellular Localization photoreceptor outer segment,extracellular space,endoplasmic reticulum,endoplasmic reticulum-Golgi intermediate compartment,plasma membrane,integral component of plasma membrane,cell surface,integral component of membrane,apical plasma membrane,microvillus me
Protein Function disease:Defects in PROM1 are the cause of cone-rod dystrophy type 12 (CORD12) [MIM:612657]. CORD12 is an inherited retinal dystrophy characterized by retinal pigment deposits visible on fundus examination, predominantly in the macular region, and initial loss of cone photoreceptors followed by rod degeneration. This leads to decreased visual acuity and sensitivity in the central visual field, followed by loss of peripheral vision. Severe loss of vision occurs earlier than in retinitis pigmentosa.,disease:Defects in PROM1 are the cause of retinal macular dystrophy type 2 (MCDR2) [MIM:608051]. MCDR2 is a bull's-eye macular dystrophy characterized by bilateral annular atrophy of retinal pigment epithelium at the macula.,disease:Defects in PROM1 are the cause of retinitis pigmentosa type 41 (RP41) [MIM:612095]; also known as retinal degeneration autosomal recessive prominin-related. RP is a retinal dystrophy belonging to the group of pigmentary retinopathies. RP is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.,disease:Defects in PROM1 are the cause of Stargardt disease type 4 (STGD4) [MIM:603786]. Stargardt disease is the most common hereditary macular degeneration. It is characterized by decreased central vision, atrophy of the macula and underlying retinal pigment epithelium, and frequent presence of prominent flecks in the posterior pole of the retina.,online information:Retina International's Scientific Newsletter,PTM:Glycosylated.,similarity:Belongs to the prominin family.,subunit:Interacts with PCDH21 and with actin filaments.,tissue specificity:Selectively expressed on CD34 hematopoietic stem and progenitor cells in adult and fetal bone marrow, fetal liver, cord blood and adult peripheral blood. Not detected on other blood cells. Also expressed in a number of non-lymphoid tissues including retina, pancreas, placenta, kidney, liver, lung, brain and heart. Found in saliva within small membrane particles.,
Usage For Research Use Only! Not for diagnostic or therapeutic procedures.
Material Safety Data Sheet

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