ITM0305
ITM0305
- Catalog: ITM0305
- Gene/Protein: GFI1
- Product Description: Immunotag™ Gfi-1 Monoclonal Antibody
504.0000
Price in reward points: 504
| Antibody Specification | |
| Datasheet | 
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| Target Protein | GFI-1 |
| Clonality | Monoclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Mouse |
| Immunogen | Purified recombinant fragment of human Gfi-1 expressed in E. Coli. |
| Specificity | Gfi-1 Monoclonal Antibody detects endogenous levels of Gfi-1 protein. |
| Purification | Affinity purification |
| Form | Ascitic fluid containing 0.03% sodium azide. |
| Gene Name | GFI1 |
| Accession No. | Q99684 P70338 |
| Alternate Names | GFI1; ZNF163; Zinc finger protein Gfi-1; Growth factor independent protein 1; Zinc finger protein 163 |
| Description | growth factor independent 1 transcriptional repressor(GFI1) Homo sapiens This gene encodes a nuclear zinc finger protein that functions as a transcriptional repressor. This protein plays a role in diverse developmental contexts, including hematopoiesis and oncogenesis. It functions as part of a complex along with other cofactors to control histone modifications that lead to silencing of the target gene promoters. Mutations in this gene cause autosomal dominant severe congenital neutropenia, and also dominant nonimmune chronic idiopathic neutropenia of adults, which are heterogeneous hematopoietic disorders that cause predispositions to leukemias and infections. Multiple alternatively spliced variants, encoding the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008], |
| Protein Expression | Bone marrow,Lung,Spleen,Testis,Thymus, |
| Subcellular Localization | nucleus,nuclear matrix,nuclear body,transcriptional repressor complex, |
| Protein Function | disease:Defects in GFI1 are a cause of autosomal dominant severe congenital neutropenia (SCN) [MIM:202700].,disease:Defects in GFI1 are a cause of dominant nonimmune chronic idiopathic neutropenia of adults (NI-CINA) [MIM:607847]. NI-CINA is a relatively mild form of neutropenia diagnosed in adults, but predisposing to leukemia in a subset of patients.,domain:The Gly/Ala-rich region may indicate that Gfi-1 is a repressor of its target genes.,function:May be a transcription factor involved in regulating the expression of genes active in the S phase during cell cycle progression in T-cells. May be involved in tumor progression (By similarity). Represses ELA2 transcription.,online information:GFI1 mutation db,similarity:Contains 6 C2H2-type zinc fingers.,subunit:Interacts with U2AF1L4., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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