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ITN0606

ITN0606
  • Gene/Protein: CPSF6 CFIM68
  • Product Description: Immunotag™ CPSF6 Polyclonal Antibody
280.0000
Price in reward points: 294

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Immunotag™ CPSF6 Polyclonal Antibody
Antibody Specification
Datasheet
Target Protein CPSF6
Clonality Polyclonal
Storage/Stability -20°C/1 year
Application WB,ELISA
Recommended Dilution WB 1:500-2000 ELISA 1:5000-20000
Concentration 1 mg/ml
Reactive Species Human,Mouse
Host Species Rabbit
Immunogen Synthesized peptide derived from part region of human protein
Specificity CPSF6 Polyclonal Antibody detects endogenous levels of protein.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
Form Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Gene Name CPSF6 CFIM68
Accession No. Q16630 Q6NVF9
Description cleavage and polyadenylation specific factor 6(CPSF6) Homo sapiens The protein encoded by this gene is one subunit of a cleavage factor required for 3' RNA cleavage and polyadenylation processing. The interaction of the protein with the RNA is one of the earliest steps in the assembly of the 3' end processing complex and facilitates the recruitment of other processing factors. The cleavage factor complex is composed of four polypeptides. This gene encodes the 68kD subunit. It has a domain organization reminiscent of spliceosomal proteins. [provided by RefSeq, Jul 2008],
Protein Expression Heart,Kidney,Leukemia,
Subcellular Localization nucleus,nucleoplasm,mRNA cleavage factor complex,membrane,intracellular ribonucleoprotein complex,paraspeckles,
Protein Function function:Component of the cleavage factor Im complex (CFIm) that plays a key role in pre-mRNA 3'-processing. Involved in association with NUDT21/CPSF5 in pre-MRNA 3'-end poly(A) site cleavage and poly(A) addition. CPSF6 binds to cleavage and polyadenylation RNA substrates.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the RRM CPSF6/7 family.,similarity:Contains 1 RRM (RNA recognition motif) domain.,subcellular location:In punctate subnuclear structures localized adjacent to nuclear speckles, called paraspeckles.,subunit:Component of the cleavage factor Im (CFIm) complex, composed at least of NUDT21/CPSF5 and CPSF6 or CPSF7. Interacts with NUDT21/CPSF5, SFRS3, SFRS7, SNRNP70 and TRA2B/SFRS10.,
Usage For Research Use Only! Not for diagnostic or therapeutic procedures.
Material Safety Data Sheet
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