ITN2463
ITN2463
- Catalog: ITN2463
- Gene/Protein: COL27A1 KIAA1870
- Product Description: Immunotag™ CORA1 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | CORA1 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from human protein, at AA range: 1551-1600 |
| Specificity | CORA1 Polyclonal Antibody detects endogenous levels of protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Gene Name | COL27A1 KIAA1870 |
| Accession No. | Q8IZC6 Q5QNQ9 Q80ZF0 |
| Description | collagen type XXVII alpha 1 chain(COL27A1) Homo sapiens This gene encodes a member of the fibrillar collagen family, and plays a role during the calcification of cartilage and the transition of cartilage to bone. The encoded protein product is a preproprotein. It includes an N-terminal signal peptide, which is followed by an N-terminal propetide, mature peptide and a C-terminal propeptide. The N-terminal propeptide contains thrombospondin N-terminal-like and laminin G-like domains. The mature peptide is a major triple-helical region. The C-terminal propeptide, also known as COLFI domain, plays crucial roles in tissue growth and repair. Mutations in this gene cause Steel syndrome. Alternatively spliced transcript variants have been found, but the full-length nature of some variants has not been determined. [provided by RefSeq, Sep 2014], |
| Protein Expression | Brain,Cartilage,Epithelium,Skin,Whole embryo, |
| Subcellular Localization | extracellular region,collagen trimer,fibrillar collagen trimer,endoplasmic reticulum lumen, |
| Protein Function | developmental stage:Detected at E67 in the primary ossification center and is tightly restricted to the pericellular region of the hypertrophic chondrocytes and lacunae at the very center of the future diaphysis. At fetal 20-week highly abundant in the hypertrophic zone at the chondroosseous junction. Weakly detected around cells in the resting and proliferative zone of the cartilaginous plate, but the intense detection occurred deep in the hypertrophic zone near the newly formed bone. Detected throughout the extracellular matrix (ECM) in this zone it is also closely situated around hypertrophic chondrocytes.,function:Plays a role during the calcification of cartilage and the transition of cartilage to bone.,similarity:Belongs to the fibrillar collagen family.,similarity:Contains 1 laminin G-like domain.,similarity:Contains 1 TSP N-terminal (TSPN) domain.,similarity:Contains 16 collagen-like domains.,subcellular location:Found on some small banded collagen fibrils and meshworks., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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