Apoptotic Inducer Set

Apoptotic Inducer Set
Ready-to-use high quality apoptosis inducers allow users an easy tool for induction of apoptosis in cultured cells. These stabilized reagent solutions have a long storage life and are easy to use. The selection of apoptosis inducers include actinomycin D, camptothecin, cycloheximide, dexamethasone, doxorubicin and etoposide. All six are supplied individually as well as a set of 6 in the Apoptosis Inducer Set.
 
Actinomycin D
A class of polypeptide antibiotics isolated from the Steptomyces soil bacteria.  Actinomycin D inhibits transcription by binding to DNA at the transcription initiation complex and therefore preventing elongation by the RNA polymerase.
Supplied as 50μl 10mM solution.
 
Camptothecin
(4-ethyl-4-hydroxy-1H-pyrano[3’,4’:6,7]indolizino[1,2-b] quinoline-3,14-(4H,12H)-dione)
A cytotoxic quinoline alkaloid that inhibits the DNA enzyme topoisomerase I (Topo I).
Supplied as 1ml 2mM solution.
 
Cycloheximide
(4-{(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl}piperidine-2,6-dione)
An inhibitor of protein synthesis by interfering with the translocation step (movement of two tRNA molecules and mRNA on ribosome) in protein synthesis, thus blocking translational elongation.
Supplied as 1ml 100mM solution.
 
Dexamethasone
(9-fluoro-11β,17,21-trihydroxy-16a-methylpregna-1,4-diene-3,20-dione)
A potent and stable glucocorticoid steroid hormone that is often used as an anti-inflammatory and anti-rheumatic drug.
The mechanism of action is not fully understood, however it is thought that it may inhibit prostaglandin synthesis.
Supplied as 1ml 10mM solution.
 
Doxorubicin
((8S,10S)-10-(4-amino-5-hydroxy-6-methyl-tetrahydro-2H-pyran-2-yloxy)-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dione)
Doxorubicin (or hydroxyldaunorubicin) is an anthracycline antibiotic that intercalates DNA, inhibiting the unwinding of DNA by topoisomerase II.
Supplied as 50μl 2mM solution.
 
Etoposide
(4’-demethyl-epipodophyllotoxin 9-[4,6-O-(R)-ethylidene-beta-D-glucopyranoside], 4’ -(dihydrogen phosphate))
An inhibitor of topoisomerase II.
Supplied as 50μl 100mM solution.
 

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API-16S
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API-16S
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Catalog Description Size Price(USD) Qty
API-16S
Apoptotic Inducer Set Set of 6
$445.00