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Cross-Linking & Modification

Download the Crosslinkers Handbook & Selection Guide            Download the Protein Labeling & Conjugation Handbook

 

 Cross-linking agents contain at least two reactive groups that are reactive towards numerous groups, including sulfhydryls, amines and carbohydrates, and create chemical covalent bonds between two or more molecules.  functional groups that can be targeted with cross-linking agents are primary amines, carboxyls, sulfhydryls,  carbohydrates and carboxylic acids. Protein molecules have many of these functional groups and therefore proteins and peptides can be readily conjugated using cross-linking agents. Cross-linking agents are used to study protein structure and function, to anchor proteins to solid  supports, preparation of immunogens, immunotoxins, and other conjugated protein reagents. G-Biosciences offers a variety of Double Do™ cross-linking agents, reaction specific buffers, and accessories for performing and facilitating crosslinking applications. These accessory tools simplify cross-linking reactions and will enable researchers to achieve highly efficient cross-linking reactions with minimal effort in reaction optimization, set-up, and procedure development

 
We offer a variety of amino acid side chain modifiers to block side chain interactions, change the charge or modify them to be more favorable for other reactions. Many denaturants, or chaotropes, are available and can disrupt water interactions resulting in the solubilization of hydrophobic proteins and peptides. Chaotropes act on proteins to unfold them and alter their three-dimensional structure. A wide selection of reagents and accessories are also available.
Sodium metaperiodate, or sodium m-periodate, is a mild oxidant that is routinely used for the conversion of cis-glycol groups in carbohydrates to reactive aldehdye groups (Figure 1).  The reactive aldehyde groups are used in chemical conjugation procedures or detection of carbohydrates.  F..
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Sulfodisuccinimidyl tartrate   Features Molecular Weight: 548.32 Spacer Arm (Å): 6.4 Reactive Toward: Primary Amines Membrane Permeable: NO Water Soluble: YES Cleavable/ Reversible: Oxidizing Agents (Periodate)    ..
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N-(ε-Maleimidocaproyloxy) sulfo succinimide ester   Features Molecular Weight: 410.33 Spacer Arm (Å): 9.4 Reactive Toward: Primary Amine + Sulfhydryl  Membrane Permeable: NO Water Soluble: YES Cleavable/ Reversible: NO    ..
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N-γ-Maleimidobutyryloxysulfosuccinimide ester   Features Molecular Weight: 382.38 Spacer Arm (Å): 6.8 Reactive Toward: Primary Amine + Sulfhydryl  Membrane Permeable: NO Water Soluble: YES Cleavable/ Reversible: NO    ..
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N-Hydroxysulfosuccinimidyl-4-azidobenzoate   Features Molecular Weight: 362.25 Spacer Arm (Å): 9.0 Reactive Toward: Primary Amines Membrane Permeable: NO Water Soluble: YES Cleavable/ Reversible: NO    ..
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m-Maleimidobenzoyl-N-hydroxysulfosuccinimide ester   Features Molecular Weight: 416.30 Spacer Arm (Å): 9.9 Reactive Toward: Primary Amine + Sulfhydryl  Membrane Permeable: NO Water Soluble: YES Cleavable/ Reversible: NO    ..
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Features Chemical Name: N-Hydroxysulfosuccinimide Reacts primarily with primary amines Water soluble Molecular weight: 217.13   Applications Ideal for cross-linking, chemical labeling and solid support immobilization Increase efficiency of EDC coupling Convert car..
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Features Chemical Name: Sulfosuccinimidyl acetate Reacts primarily with primary amines Reacts at pH 7-9 Water soluble Molecular weight: 259.17   Applications Blocks primary amines by acylation    ..
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Sulfosuccinimidyl (4-azidophenyl)-1,3’-dithiopropionate   Features Molecular Weight: 454.44 Spacer Arm (Å): 13.9 Reactive Toward: Primary Amines Membrane Permeable: NO Water Soluble: YES Cleavable/ Reversible: Reducing Agents (Thiol)    ..
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Sulfosuccinimidyl 2-(m-azido-o-nitrobenzamido)-ethyl-1,3’-dithiopropionate   Features Molecular Weight: 570.51 Spacer Arm (Å): 18.5 Reactive Toward: Primary Amines Membrane Permeable: NO Water Soluble: YES Cleavable/ Reversible: Reducing Agents (Thiol) ..
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Sulfosuccinimidyl-2-(ρ-azidosalicylamido)ethyl-1,3-dithiopropionate   Features Molecular Weight: 541.51 Spacer Arm (Å): 18.9 Reactive Toward: Primary Amines Membrane Permeable: NO Water Soluble: YES Cleavable/ Reversible: Reducing Agents (Thiol)    ..
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G-Biosciences water-soluble Bolton-Hunter Reagent (Sulfo-SHPP) conjugates tyrosine-like groups to end-terminal α-amino groups or ε-amino groups of lysine to increase the number of tyrosyl groups that can be iodinated by iodine-125 labeling procedures.   Radioactive iodine (..
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