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FTAC6



Fluorinated surfactants are unable to extract proteins from membrane, but are useful for membrane protein stabilization in subsequent purification steps as they do not strip natural lipids and other co-factors from the proteins. In addition, the bulky fluorinated tails can not penetrate into the interior and disrupt structure. Fluorinated surfactants often decrease non-specific aggregation and are thought to result in improved distribution on cryo-EM grids and better vitrification for cryo-EM data collection. They are also reported to increase crystallizability.
 
Specifications
  • Compound Name: FTAC6
  • IUPAC Name: S-(poly(tris(hydroxymethyl)acrylamidomethane)-(3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorothiooctyl) DPn=6
  • Application: Membrane Protein Stabilization
  • Surfactant type: Fluorinated surfactant
  • Molecular Formula: n/a
  • Molecular Weight: ~1400 g/mol
  • Percent Composition: n/a
  • Purity (HPLC, 214nm): n/d
  • Retention time (RP18 HPLC): tR = 10.5 min
  • Physical State: White powder
  • Stability: Store in <-20°C freezer for up to one year
  • Solubility: Soluble in water (18.5mM), methanol and DMSO
  • Critical Micelle Concentration: 0.37mM
Protocol
786-1530
786-1531
786-1532
Material Safety Data Sheet
786-1530
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786-1531
English_US
Danish
Dutch
English_UK
French
German
Spanish
Norwegian
Portuguese
Finnish
Swedish
Polish
786-1532
English_US
Danish
Dutch
English_UK
French
German
Spanish
Norwegian
Portuguese
Finnish
Swedish
Polish

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