G-Biocides

Biocides either kill or inhibit growth of microorganisms. Biocides are generally non-antibiotic chemical agents. Biocides acts on metabolic and cellular process, either inhibit, disrupt grow process or lyse microorganisms. An ideal biocide should have a wide spectrum activity, and potent even at low concentration.

G-Biosciences offers a wide range of biocides and preservatives optimized for research use. These biocide and preservatives when added to buffers, reagents, and solutions, will suppress, prevent, and/or eliminate microbial growths. Suitable as preservative, for research or testing reagents such as buffers, reagents, blocking solutions for ELISA or Western blots, chromatography resins and Immunoglobulins storage solutions - increases their useful shelf life.

 G -Biocide-I:  A broad spectrum antimetabolite that target Krebs cycle of microorganisms. It inhibits growth of both bacteria and fungi.  It is based on optimized concentration of 5-Chlroro-2-methyl-4-siothiazolin-3-one (CMIT) and 2-methyl-4-isothiazolin-3-one (MIT).  G-Biocide-I attacks and inhibits the central metabolic cycle of the cell, the Krebs cycle. It inhibits succinate dehydrogenase and NADH dehydrogenase enzymes of the Krebs cycle. It also inhibits pyruvate dehydrogenase, lactate dehydrogenase and alcohol dehydrogenase.

G-Biocide-II: A Thimerosal-based preservative. Thimerosal is an organomercury compound and derivative of thiosalicyclic acid. It has antibacterial and anti-fungal properties. Although its mechanism is not fully understood, it is known to inhibit sulfhydryl containing active site of various enzymes and binds sulfhydryl compounds such as glutathione, cysteine, and SH groups of proteins. Furthermore, thimerosal activates the InsP3 calcium channel on endoplasmic reticular membrane and triggers release of calcium from intracellular stores.

G-Biocide-III:  It is a sodium azide based preservative. Azide anions bind to trivalent iron in porphyrin complexes and inhibit the activity of catalase, peroxidases, and cytochrome oxidases. It acts as bacteriostatic by inhibiting cytochrome oxidase.