Pioglitazone HCl
Pioglitazone HCl
Pioglitazone HCl
| Bioassays Specification | |
| Bio-Activity | PPARg agonist |
| Chemical Name | 5-[[4-[2-(5-Ethyl-2-pyridinyl)ethoxy]phenyl]methyl]-2,4-thiazolidinedione hydrochloride |
| Function / Pharmacology | Pioglitazone is a clinically useful antidiabetic drug.1 It is a selective agonist of the human peroxisome proliferator-activated receptor γ1(PPARγ1; EC50 = 490 nM2, 550nM3) with weak agonist activity at PPARα and no activity at PPARδ.2 |
| CAS# | 112529-15-4 |
| MW | 392.9 |
| Molecular Formula | C19H20N2O3S • HCl |
| Solubility | Soluble in DMSO (up to 25 mg/ml). |
| Supplied | powder |
| Storage as supplied | RT |
| Ship temp | Ambient |
| References | 1) Merck 14:7452 / 2) Sakamoto et al. (2000), Activation of human peroxisome proliferator-activated receptor (PPAR) subtypes by pioglitazone; Biochem.Biophys.Res.Commun., 278 704 / 3) Wilson et al. (2000), The PPARs: From Orphan Receptors to Drug Discovery; J.Med.Chem., 43 527 |
| Protein Specification | |
| Purity | >98% |
| Bioassays Specification | |
| Bio-Activity | PPARg agonist |
| Chemical Name | 5-[[4-[2-(5-Ethyl-2-pyridinyl)ethoxy]phenyl]methyl]-2,4-thiazolidinedione hydrochloride |
| Function / Pharmacology | Pioglitazone is a clinically useful antidiabetic drug.1 It is a selective agonist of the human peroxisome proliferator-activated receptor γ1(PPARγ1; EC50 = 490 nM2, 550nM3) with weak agonist activity at PPARα and no activity at PPARδ.2 |
| CAS# | 112529-15-4 |
| MW | 392.9 |
| Molecular Formula | C19H20N2O3S • HCl |
| Solubility | Soluble in DMSO (up to 25 mg/ml). |
| Supplied | powder |
| Storage as supplied | RT |
| Ship temp | Ambient |
| References | 1) Merck 14:7452 / 2) Sakamoto et al. (2000), Activation of human peroxisome proliferator-activated receptor (PPAR) subtypes by pioglitazone; Biochem.Biophys.Res.Commun., 278 704 / 3) Wilson et al. (2000), The PPARs: From Orphan Receptors to Drug Discovery; J.Med.Chem., 43 527 |
| Protein Specification | |
| Purity | >98% |