| Catalog | Description | Size | Price (USD) | Qty |
|---|---|---|---|---|
| GBM-1339-1MG | Ilomastat (GM-6001) | 1mg | $110.00 | |
| GBM-1339-5MG | Ilomastat (GM-6001) | 5mg | $420.00 |
| Bioassays Specification | |
| Bio-Activity | MMP inhibitor (pan-specific) |
| Chemical Name | N-[(2R)-2-(Hydroxamidocarbonylmethyl)-4-methylpentanoyl]-L-tryptophan methylamide |
| Function / Pharmacology | Potent pan-specific inhibitor of matrix metalloproteinases (MMPs).1 Ki values have been reported for the following human MMPs: MMP-1, 0.4nM; MMP-2, 0.5nM; MMP-3, 27nM; MMP-7, 3.7nM; MMP-8, 0.1nM; MMP-9, 0.2nM; MMP-12, 3.6nM; MMP-14, 13.4nM; MMP-26, 0.36nM.2-4 Also inhibits MMP-10, MMP-13, MMP-15, MMP-17, MMP-20, MMP-21, TACE and ADAM19. |
| CAS# | 142880-36-2 |
| MW | 388.46 |
| Molecular Formula | C20H28N4O4 |
| Solubility | Soluble in DMSO (up to 10 mg/ml) or in Ethanol (up to 10 mg/ml). |
| Supplied | powder |
| Storage as supplied | -20°C |
| Ship temp | Ambient |
| References | 1) Saghatelian, et al. (2004) Activity-based probes for the proteomic profiling of metalloproteases Proc. Natl. Acad. Sci. USA 101 10000 / 2) Galardy et al.(1994) Low molecular weight inhibitors in corneal ulceration, Ann.N.Y.Acad.Sci 732 315 / 3) Yamamoto et al.(1998) Inhibition of Membrane-Type 1 Matrix Metalloproteinase by Hydroxamate Inhibitors: An Examination of the Subsite Pocket, J. Med. Chem. 41 1209 / 4) Park et al. (2003) The intermediate S1’ pocket of the endometase/matrilysin-2 active site revealed by enzyme inhibition kinetic studies, protein sequence analyses, and homology modeling J. Biol. Chem. 278 51646 |
| Antibody Specification | |
| Alternate Names | GM-6001 |
| Protein Specification | |
| Purity | >98% |
| Bioassays Specification | |
| Bio-Activity | MMP inhibitor (pan-specific) |
| Chemical Name | N-[(2R)-2-(Hydroxamidocarbonylmethyl)-4-methylpentanoyl]-L-tryptophan methylamide |
| Function / Pharmacology | Potent pan-specific inhibitor of matrix metalloproteinases (MMPs).1 Ki values have been reported for the following human MMPs: MMP-1, 0.4nM; MMP-2, 0.5nM; MMP-3, 27nM; MMP-7, 3.7nM; MMP-8, 0.1nM; MMP-9, 0.2nM; MMP-12, 3.6nM; MMP-14, 13.4nM; MMP-26, 0.36nM.2-4 Also inhibits MMP-10, MMP-13, MMP-15, MMP-17, MMP-20, MMP-21, TACE and ADAM19. |
| CAS# | 142880-36-2 |
| MW | 388.46 |
| Molecular Formula | C20H28N4O4 |
| Solubility | Soluble in DMSO (up to 10 mg/ml) or in Ethanol (up to 10 mg/ml). |
| Supplied | powder |
| Storage as supplied | -20°C |
| Ship temp | Ambient |
| References | 1) Saghatelian, et al. (2004) Activity-based probes for the proteomic profiling of metalloproteases Proc. Natl. Acad. Sci. USA 101 10000 / 2) Galardy et al.(1994) Low molecular weight inhibitors in corneal ulceration, Ann.N.Y.Acad.Sci 732 315 / 3) Yamamoto et al.(1998) Inhibition of Membrane-Type 1 Matrix Metalloproteinase by Hydroxamate Inhibitors: An Examination of the Subsite Pocket, J. Med. Chem. 41 1209 / 4) Park et al. (2003) The intermediate S1’ pocket of the endometase/matrilysin-2 active site revealed by enzyme inhibition kinetic studies, protein sequence analyses, and homology modeling J. Biol. Chem. 278 51646 |
| Antibody Specification | |
| Alternate Names | GM-6001 |
| Protein Specification | |
| Purity | >98% |
