Propargylglycine (R,S)
Propargylglycine (R,S)
Propargylglycine (R,S)
| Bioassays Specification | |
| Bio-Activity | H2S synthase inhibitor |
| Chemical Name | 2-Amino-4-pentynoic acid |
| Function / Pharmacology | Irreversible inhibitor of the hydrogen sulfide biosynthesis enzyme, cystathione-γ-lyase. It inhibits H2S production in rat liver preparations (IC50=55 μM) and inhibits the rise in plasma H2S in rats with hemorrhagic shock2. It reduces inflammation in a rodent carrageenan-induced hindpaw edema model3. Ameliorates gentamycin-induced nephrotoxicity1. |
| CAS# | 64165-64-6 |
| MW | 113.12 |
| Molecular Formula | C5H7NO2 |
| Solubility | Soluble in DMSO (up to 10 mg/ml) or in Water (up tp 10 mg/ml). |
| Supplied | powder |
| Storage as supplied | RT |
| Ship temp | Ambient |
| References | 1) Dam et al. (2012), Inhibition of cystathione gamma-lyase and the biosynthesis of endogenous hydrogen sulphide ameliorares gentamicin-induced nephrotoxicity; Eur. J. Pharmacol., 685 165 2) Mok et al. (2004), Role of hydrogen sulphide in haemorrhagic shock in the rat: protective effect of inhibitors of hydrogen sulphide biosynthesis; Br. J. Pharmacol., 143 881 3) Bhatia et al. (2005),Hydrogen sulphide is a mediator of carrageenan-induced hindpaw edema in the rat; Br. J. Pharmacol., 145 141 |
| Protein Specification | |
| Purity | >98% |
| Bioassays Specification | |
| Bio-Activity | H2S synthase inhibitor |
| Chemical Name | 2-Amino-4-pentynoic acid |
| Function / Pharmacology | Irreversible inhibitor of the hydrogen sulfide biosynthesis enzyme, cystathione-γ-lyase. It inhibits H2S production in rat liver preparations (IC50=55 μM) and inhibits the rise in plasma H2S in rats with hemorrhagic shock2. It reduces inflammation in a rodent carrageenan-induced hindpaw edema model3. Ameliorates gentamycin-induced nephrotoxicity1. |
| CAS# | 64165-64-6 |
| MW | 113.12 |
| Molecular Formula | C5H7NO2 |
| Solubility | Soluble in DMSO (up to 10 mg/ml) or in Water (up tp 10 mg/ml). |
| Supplied | powder |
| Storage as supplied | RT |
| Ship temp | Ambient |
| References | 1) Dam et al. (2012), Inhibition of cystathione gamma-lyase and the biosynthesis of endogenous hydrogen sulphide ameliorares gentamicin-induced nephrotoxicity; Eur. J. Pharmacol., 685 165 2) Mok et al. (2004), Role of hydrogen sulphide in haemorrhagic shock in the rat: protective effect of inhibitors of hydrogen sulphide biosynthesis; Br. J. Pharmacol., 143 881 3) Bhatia et al. (2005),Hydrogen sulphide is a mediator of carrageenan-induced hindpaw edema in the rat; Br. J. Pharmacol., 145 141 |
| Protein Specification | |
| Purity | >98% |