| Catalog | Description | Size | Price (USD) | Qty |
|---|---|---|---|---|
| GBM-1439-10MG | ML-SA1 | 10mg | $158.00 | |
| GBM-1439-50MG | ML-SA1 | 50mg | $630.00 |
| Bioassays Specification | |
| Bio-Activity | TRPML channel activator |
| Chemical Name | 2-[2-(3,4-Dihydro-2,2,4-trimethyl-1(2H)-quinolinyl)-2-oxoethyl]-1H-isoindole-1,3(2H)-dione |
| Function / Pharmacology | TRPML 1,2 and 3 channel activator.1 Does not activate TRPM2, TRPV2, TRPV3, TRPC6 or TRPA1 channels.2 ML-SA1 robustly activates whole cell TRPML1-4A and whole-endolysosome TRPML1 and is comparable (10 μM) to the effect of the endogenous TRPML agonist, PI(3,5)P2 (1 μM).2 Thus it is a useful chemical tool for studying the functions of TRPMLs. It induces TRPML-mediated Ca2+ release from lysosomes which corrects trafficking defects and reduces cholesterol accumulation in Niemann-Pick type C macrophages.2,3 Reduces intralysosomal Ca2+ level rescuing abnormal lysosomal storage in FIG4-deficient cells.4 |
| CAS# | 332382-54-4 |
| MW | 362.43 |
| Molecular Formula | C22H22N2O3 |
| Solubility | Soluble in DMSO (up to 20 mg/ml with warming) or in Ethanol (up to 10 mg/ml). |
| Supplied | powder |
| Storage as supplied | RT |
| Ship temp | Ambient |
| References | 1) Grimm et al. (2010), Small molecule activators of TRPML3; Mol. Chem. Biol., 17 135 2) Shen et al. (2012), Lipid storage disorders block lysosomal trafficking by inhibiting a TRP channel and lysosomal calcium release; Nature Commun., 3 731 3) Weiss et al. (2012), Cross-talk between TRPML1 channel, lipids and lysosomal storage diseases; Commun. Integer. Biol., 5 111 4) Zou et al. (2015), Reactivation of lysosomal Ca2+ Efflux Rescues Abnormal Lysosomal Storage in FIG4-Deficient Cells; J. Neurosci.. 35 6801 |
| Protein Specification | |
| Purity | >98% |
| Bioassays Specification | |
| Bio-Activity | TRPML channel activator |
| Chemical Name | 2-[2-(3,4-Dihydro-2,2,4-trimethyl-1(2H)-quinolinyl)-2-oxoethyl]-1H-isoindole-1,3(2H)-dione |
| Function / Pharmacology | TRPML 1,2 and 3 channel activator.1 Does not activate TRPM2, TRPV2, TRPV3, TRPC6 or TRPA1 channels.2 ML-SA1 robustly activates whole cell TRPML1-4A and whole-endolysosome TRPML1 and is comparable (10 μM) to the effect of the endogenous TRPML agonist, PI(3,5)P2 (1 μM).2 Thus it is a useful chemical tool for studying the functions of TRPMLs. It induces TRPML-mediated Ca2+ release from lysosomes which corrects trafficking defects and reduces cholesterol accumulation in Niemann-Pick type C macrophages.2,3 Reduces intralysosomal Ca2+ level rescuing abnormal lysosomal storage in FIG4-deficient cells.4 |
| CAS# | 332382-54-4 |
| MW | 362.43 |
| Molecular Formula | C22H22N2O3 |
| Solubility | Soluble in DMSO (up to 20 mg/ml with warming) or in Ethanol (up to 10 mg/ml). |
| Supplied | powder |
| Storage as supplied | RT |
| Ship temp | Ambient |
| References | 1) Grimm et al. (2010), Small molecule activators of TRPML3; Mol. Chem. Biol., 17 135 2) Shen et al. (2012), Lipid storage disorders block lysosomal trafficking by inhibiting a TRP channel and lysosomal calcium release; Nature Commun., 3 731 3) Weiss et al. (2012), Cross-talk between TRPML1 channel, lipids and lysosomal storage diseases; Commun. Integer. Biol., 5 111 4) Zou et al. (2015), Reactivation of lysosomal Ca2+ Efflux Rescues Abnormal Lysosomal Storage in FIG4-Deficient Cells; J. Neurosci.. 35 6801 |
| Protein Specification | |
| Purity | >98% |
