| Catalog | Description | Size | Price (USD) | Qty |
|---|---|---|---|---|
| GBM-1538-5MG | GAC Inhibitor 968 | 5mg | $105.00 | |
| GBM-1538-25MG | GAC Inhibitor 968 | 25mg | $420.00 |
| Bioassays Specification | |
| Bio-Activity | Glutaminase C inhibitor |
| Chemical Name | 5-(3-bromo-4-(dimethylamino)phenyl)-2,2-dimethyl-2,3,5,6-tetrahydrobenzo[a]-phenanthridin-4(1H)-one |
| Function / Pharmacology | Allosteric inhibitor of glutaminase C (GAC)1. Inhibition of GAC blocks oncogenic transformation induced by Rho GTPases in fibroblasts and B lymphoma cells with no effect on normal cells2. Inhibits liver-type glutaminase GLS2 and suppresses breast tumor growth in vivo3,4. Reverses acquired erlotinib resistance in non-small cell lung cancer5. |
| CAS# | 311795-38-7 |
| MW | 475.4 |
| Molecular Formula | C27H27BrN2O |
| Solubility | Soluble in DMSO (up to (11 mg/ml); or ethanol (up to 1 mg/ml, warm) |
| Supplied | powder |
| Storage as supplied | RT |
| Ship temp | Ambient |
| References | 1.CA Stalnecker et al. Proc. Natl. Acad. Sci. USA 2015 112:394 2.J-B Wang et al. Cancer Cell 2010 18:207 3.WP Katt et al. Mol. Cancer Ther. 2012 11:1269 4.MJ Lukey et al. Cell Reports 2019 29:76 5.C Xie et al. Oncotarget 2016 7:610 |
| Protein Specification | |
| Purity | >98% |
| Bioassays Specification | |
| Bio-Activity | Glutaminase C inhibitor |
| Chemical Name | 5-(3-bromo-4-(dimethylamino)phenyl)-2,2-dimethyl-2,3,5,6-tetrahydrobenzo[a]-phenanthridin-4(1H)-one |
| Function / Pharmacology | Allosteric inhibitor of glutaminase C (GAC)1. Inhibition of GAC blocks oncogenic transformation induced by Rho GTPases in fibroblasts and B lymphoma cells with no effect on normal cells2. Inhibits liver-type glutaminase GLS2 and suppresses breast tumor growth in vivo3,4. Reverses acquired erlotinib resistance in non-small cell lung cancer5. |
| CAS# | 311795-38-7 |
| MW | 475.4 |
| Molecular Formula | C27H27BrN2O |
| Solubility | Soluble in DMSO (up to (11 mg/ml); or ethanol (up to 1 mg/ml, warm) |
| Supplied | powder |
| Storage as supplied | RT |
| Ship temp | Ambient |
| References | 1.CA Stalnecker et al. Proc. Natl. Acad. Sci. USA 2015 112:394 2.J-B Wang et al. Cancer Cell 2010 18:207 3.WP Katt et al. Mol. Cancer Ther. 2012 11:1269 4.MJ Lukey et al. Cell Reports 2019 29:76 5.C Xie et al. Oncotarget 2016 7:610 |
| Protein Specification | |
| Purity | >98% |
