| Catalog | Description | Size | Price (USD) | Qty |
|---|---|---|---|---|
| GBM-2112-10MG | Valinomycin | 10mg | $89.00 | |
| GBM-2112-50MG | Valinomycin | 50mg | $294.00 |
| Bioassays Specification | |
| Bio-Activity | Potassium ionophore |
| Chemical Name | Cyclo(L-Val-D-HyIva-D-Val-L-Lac-)3 |
| Function / Pharmacology | Valinomycin is a selective K+ ionophore capable of transporting potassium ions through lipid membranes.1 It can induce apoptosis in cells by causing a rapid loss of mitochondrial membrane potential via potassium efflux.2,3 |
| CAS# | 2001-95-8 |
| MW | 1111.35 |
| Molecular Formula | C54H90N6O18 |
| Solubility | Soluble in DMSO (up to 10 mg/ml). |
| Supplied | powder |
| Storage as supplied | -20°C |
| Ship temp | Ambient |
| References | 1) Pressman, (1976) Biological applications of ionophores; Annu.Rev.Biochem. 45 501 / 2) Furlong et al., (1998) Induction of apoptosis by valinomycin: mitochondrial permeability transition causes intracellular acidification Cell Death Diff. 5 214 / 3) Inai et al. (1997) Valinomycin induces apoptosis of ascites hepatoma cells (AH-130) in relation to mitochondrial membrane potential; Cell Struc.Funct. 22 555 |
| Protein Specification | |
| Purity | >98% |
| Bioassays Specification | |
| Bio-Activity | Potassium ionophore |
| Chemical Name | Cyclo(L-Val-D-HyIva-D-Val-L-Lac-)3 |
| Function / Pharmacology | Valinomycin is a selective K+ ionophore capable of transporting potassium ions through lipid membranes.1 It can induce apoptosis in cells by causing a rapid loss of mitochondrial membrane potential via potassium efflux.2,3 |
| CAS# | 2001-95-8 |
| MW | 1111.35 |
| Molecular Formula | C54H90N6O18 |
| Solubility | Soluble in DMSO (up to 10 mg/ml). |
| Supplied | powder |
| Storage as supplied | -20°C |
| Ship temp | Ambient |
| References | 1) Pressman, (1976) Biological applications of ionophores; Annu.Rev.Biochem. 45 501 / 2) Furlong et al., (1998) Induction of apoptosis by valinomycin: mitochondrial permeability transition causes intracellular acidification Cell Death Diff. 5 214 / 3) Inai et al. (1997) Valinomycin induces apoptosis of ascites hepatoma cells (AH-130) in relation to mitochondrial membrane potential; Cell Struc.Funct. 22 555 |
| Protein Specification | |
| Purity | >98% |
