| Catalog | Description | Size | Price (USD) | Qty |
|---|---|---|---|---|
| GBM-2173-5MG | SB-203580 | 5mg | $126.00 | |
| GBM-2173-25MG | SB-203580 | 25mg | $504.00 |
| Bioassays Specification | |
| Bio-Activity | p38 MAP kinase inhibitor |
| Chemical Name | 4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)imidazole |
| Function / Pharmacology | A potent and selective inhibitor of p38 MAP kinase, IC50=50 and 500 nM for p38 and p38β2 respectively. No other kinases (in a panel of 30) were significantly inhibited including p38γ and δ at 10 μM2. A potent inhibitor of inflammatory cytokine production (IC50=15-25 mg/kg in mice and rats) in animal models of arthritis, bone resorption, endotoxin shock and immune function3. |
| CAS# | 152121-47-6 |
| MW | 377.44 |
| Molecular Formula | C21H16N3OSF |
| Solubility | Soluble in DMSO (up to 100 mg/ml) or in Ethanol (up to 10 mg/ml with warming). |
| Supplied | powder |
| Storage as supplied | -20°C |
| Ship temp | Ambient |
| References | 1) Cuenda et al. (1995), SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1; FEBS Lett., 364 229 / 2) Davies et al. (2000), Specificity and mechansim of action of some commonly used protein kinase inhibitors; Biochem. J., 351 95 / 3) Badger et al. (1996), Pharmacological profile of SB 203580, a selective inhibitor of cytokine suppressive binding protein/p38 kinase, in animal models of arthritis, bone resorption, endotoxin shock and immune function; Pharmacol. Exp. Ther. 279 1453 |
| Protein Specification | |
| Purity | >98% |
| Bioassays Specification | |
| Bio-Activity | p38 MAP kinase inhibitor |
| Chemical Name | 4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)imidazole |
| Function / Pharmacology | A potent and selective inhibitor of p38 MAP kinase, IC50=50 and 500 nM for p38 and p38β2 respectively. No other kinases (in a panel of 30) were significantly inhibited including p38γ and δ at 10 μM2. A potent inhibitor of inflammatory cytokine production (IC50=15-25 mg/kg in mice and rats) in animal models of arthritis, bone resorption, endotoxin shock and immune function3. |
| CAS# | 152121-47-6 |
| MW | 377.44 |
| Molecular Formula | C21H16N3OSF |
| Solubility | Soluble in DMSO (up to 100 mg/ml) or in Ethanol (up to 10 mg/ml with warming). |
| Supplied | powder |
| Storage as supplied | -20°C |
| Ship temp | Ambient |
| References | 1) Cuenda et al. (1995), SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1; FEBS Lett., 364 229 / 2) Davies et al. (2000), Specificity and mechansim of action of some commonly used protein kinase inhibitors; Biochem. J., 351 95 / 3) Badger et al. (1996), Pharmacological profile of SB 203580, a selective inhibitor of cytokine suppressive binding protein/p38 kinase, in animal models of arthritis, bone resorption, endotoxin shock and immune function; Pharmacol. Exp. Ther. 279 1453 |
| Protein Specification | |
| Purity | >98% |
