Cilastatin Na
Cilastatin Na
Cilastatin Na
| Catalog | Description | Size | Price (USD) | Qty |
|---|---|---|---|---|
| GBM-2233-10MG | Cilastatin Na | 10mg | $126.00 | |
| GBM-2233-50MG | Cilastatin Na | 50mg | $504.00 |
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Description
Dipeptidase inhibitor; DPEP1 inhibitor
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Specifications
Bioassays Specification Bio-Activity Dipeptidase inhibitor; DPEP1 inhibitor Chemical Name (2Z)-7-[[(2R)-2-Amino-2-carboxyethyl]thio]-2-[[[(1S)-2,2-dimethylcyclopropyl]-carbonyl]amino]-2-heptenoic acid, sodium salt Function / Pharmacology Dehydropeptidase-1 inhibitor. Inhibits the proteolytic conversion of leukotriene D4 to E4.1 Inhibits the mammalian β-lactamase renal dipeptidase (dehydropeptidase-1, DPEP1) and thus is used as an antibacterial adjunct to extend the half-life of β-lactam antibiotics.2 Cilastatin also inhibits bacterial metallo-β-lactamase and thereby may block resistance to the carbapenem family of antibiotics in certain bacteria.3 Suppresses invasion and metastasis of DPEP1-expressing tumor cells.4 CAS# 81129-83-1 MW 380.43 Molecular Formula C16H25N2O5S • Na Solubility Soluble in DMSO (up to 3 mg/ml) or in Water (up to 35 mg/ml) Supplied powder Storage as supplied -20°C Ship temp Ambient References 1) White et al. (1999), A continuous fluorometric assay for Leukotriene D4 hydrolase; Anal. Biochem., 268 245 2) Graham et al. (1987), Inhibition of the mammalian beta-lactamase renal dipeptidase (dehydropeptidase-I) by (Z)-2-acylamino-3-substituted propenoic acids; J. Med. Chem., 30 1074 3) Keynan et al. (1995), The renal membrane dipeptidase (dehydropeptidase I) inhibitor, cilastatin, inhibits the bacterial metallo-beta-lactamase enzyme CphA; Antimicreob. Agents Chemother., 39 1629 4) Park et al. (2016), Dehydropeptidase 1 promotes metastasis through regulation of E-cadherin expression in colon cancer; Oncotarget, 7 9501 Antibody Specification Alternate Names MK 0791 Protein Specification Purity >98% - Reviews
| Bioassays Specification | |
| Bio-Activity | Dipeptidase inhibitor; DPEP1 inhibitor |
| Chemical Name | (2Z)-7-[[(2R)-2-Amino-2-carboxyethyl]thio]-2-[[[(1S)-2,2-dimethylcyclopropyl]-carbonyl]amino]-2-heptenoic acid, sodium salt |
| Function / Pharmacology | Dehydropeptidase-1 inhibitor. Inhibits the proteolytic conversion of leukotriene D4 to E4.1 Inhibits the mammalian β-lactamase renal dipeptidase (dehydropeptidase-1, DPEP1) and thus is used as an antibacterial adjunct to extend the half-life of β-lactam antibiotics.2 Cilastatin also inhibits bacterial metallo-β-lactamase and thereby may block resistance to the carbapenem family of antibiotics in certain bacteria.3 Suppresses invasion and metastasis of DPEP1-expressing tumor cells.4 |
| CAS# | 81129-83-1 |
| MW | 380.43 |
| Molecular Formula | C16H25N2O5S • Na |
| Solubility | Soluble in DMSO (up to 3 mg/ml) or in Water (up to 35 mg/ml) |
| Supplied | powder |
| Storage as supplied | -20°C |
| Ship temp | Ambient |
| References | 1) White et al. (1999), A continuous fluorometric assay for Leukotriene D4 hydrolase; Anal. Biochem., 268 245 2) Graham et al. (1987), Inhibition of the mammalian beta-lactamase renal dipeptidase (dehydropeptidase-I) by (Z)-2-acylamino-3-substituted propenoic acids; J. Med. Chem., 30 1074 3) Keynan et al. (1995), The renal membrane dipeptidase (dehydropeptidase I) inhibitor, cilastatin, inhibits the bacterial metallo-beta-lactamase enzyme CphA; Antimicreob. Agents Chemother., 39 1629 4) Park et al. (2016), Dehydropeptidase 1 promotes metastasis through regulation of E-cadherin expression in colon cancer; Oncotarget, 7 9501 |
| Antibody Specification | |
| Alternate Names | MK 0791 |
| Protein Specification | |
| Purity | >98% |