DMOG
DMOG
DMOG
| Catalog | Description | Size | Price (USD) | Qty |
|---|---|---|---|---|
| GBM-2371-50MG | DMOG | 50mg | $126.00 | |
| GBM-2371-100MG | DMOG | 100mg | $231.00 |
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Description
Prolyl hydroxylase inhibitor
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Specifications
Bioassays Specification Bio-Activity Prolyl hydroxylase inhibitor Chemical Name N-(2-Methoxy-2-oxoacetyl)glycine methyl ester Function / Pharmacology Inhibits PHD or prolyl hydroxylase domain-containing proteins, activating HIF1α1,2 and inhibiting JMJD2A (IC50 = 2.5 μM)3. Displays neuroprotective effects. Inhibits neuronal cell death caused by neurotrophin deprivation4. Prevents activation of the ATR/CHK1/p53 pathway and suppresses apoptosis induced by DNA damage5. CAS# 89464-63-1 MW 175.14 Molecular Formula C6H9NO5 Solubility Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml). Supplied powder Storage as supplied -20°C / protect from light Ship temp Ambient References 1) Asikainen et al. (2005), Activation of hypoxia-inducible factors in hyperoxia through prolyl 4-hydroxylase blockade in cells and explants of primate lung; Proc. Natl. Acad. Sci. USA, 102 10212 2) Jaakkola et al. (2001), Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation; Science, 292 468 3) Hamada et al. (2009), Synthesis and activity of N-oxalylglycine and it’s derivatives as jumonji C-domain-containing histone lysine demethylase inhibitors; Bioorg. Med. Chem. Lett., 19 2852 4) Lomb et al. (2009), Prolyl hydroxylase inhibitors depend on extracellular glucose and hypoxia-inducible factor (HIF)-2alpha to inhibit cell death caused by nerve growth factor deprivation: evidence that HIF-2alpha has a role in NGF-promoted survival of sympathetic neurons; Mol. Pharmacol., 75 1198 5) Xie et al. (2012), PHD3-dependent hydroxylation of HCLK2 promotes the DNA damage response; J. Clin. Invest., 122 2827 Antibody Specification Alternate Names Dimethyloxalylglycine Protein Specification Purity >98% - Reviews
| Bioassays Specification | |
| Bio-Activity | Prolyl hydroxylase inhibitor |
| Chemical Name | N-(2-Methoxy-2-oxoacetyl)glycine methyl ester |
| Function / Pharmacology | Inhibits PHD or prolyl hydroxylase domain-containing proteins, activating HIF1α1,2 and inhibiting JMJD2A (IC50 = 2.5 μM)3. Displays neuroprotective effects. Inhibits neuronal cell death caused by neurotrophin deprivation4. Prevents activation of the ATR/CHK1/p53 pathway and suppresses apoptosis induced by DNA damage5. |
| CAS# | 89464-63-1 |
| MW | 175.14 |
| Molecular Formula | C6H9NO5 |
| Solubility | Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml). |
| Supplied | powder |
| Storage as supplied | -20°C / protect from light |
| Ship temp | Ambient |
| References | 1) Asikainen et al. (2005), Activation of hypoxia-inducible factors in hyperoxia through prolyl 4-hydroxylase blockade in cells and explants of primate lung; Proc. Natl. Acad. Sci. USA, 102 10212 2) Jaakkola et al. (2001), Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation; Science, 292 468 3) Hamada et al. (2009), Synthesis and activity of N-oxalylglycine and it’s derivatives as jumonji C-domain-containing histone lysine demethylase inhibitors; Bioorg. Med. Chem. Lett., 19 2852 4) Lomb et al. (2009), Prolyl hydroxylase inhibitors depend on extracellular glucose and hypoxia-inducible factor (HIF)-2alpha to inhibit cell death caused by nerve growth factor deprivation: evidence that HIF-2alpha has a role in NGF-promoted survival of sympathetic neurons; Mol. Pharmacol., 75 1198 5) Xie et al. (2012), PHD3-dependent hydroxylation of HCLK2 promotes the DNA damage response; J. Clin. Invest., 122 2827 |
| Antibody Specification | |
| Alternate Names | Dimethyloxalylglycine |
| Protein Specification | |
| Purity | >98% |