Dibutyryl cAMP
Dibutyryl cAMP
Dibutyryl cAMP
| Catalog | Description | Size | Price (USD) | Qty |
|---|---|---|---|---|
| GBM-2627-25MG | Dibutyryl cAMP | 25mg | $74.00 | |
| GBM-2627-100MG | Dibutyryl cAMP | 100mg | $210.00 |
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Description
PKA activator
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Specifications
Bioassays Specification Bio-Activity PKA activator Chemical Name N6,O2'-Dibutyryl adenosine 3',5'-cyclic monophosphate sodium salt Function / Pharmacology Cell-permeable cAMP analog which mimics the effect of endogenous cAMP when applied to cells.1 Activates PKA.2,3 Induces morphological differentiation of astrocytes.4 Promotes differentiation of dopaminergic neurons from hPSCs (in cocktails with other agents).5 CAS# 16980-89-5 MW 491.4 Molecular Formula C18H23N5O8P • Na Solubility Soluble in DMSO (50 mg/ml); water (50 mg/ml) Supplied powder Storage as supplied -20°C Ship temp Blue ice References 1) Bartsch et al. (2003), Bioactivatable, membrane-permeant analogs of cyclic nucleotides as biological tools for growth control of C6 glioma cells; Biol. Chem., 384 1321 2) Carranza et al. (1998), Protein kinase A induces recruitment of active Na+,K+-ATPase units to the plasma membrane of rat proximal convoluted tubule cells; J. Physiol., 15 511 3) Hei et al. (1991), Lack of correlation between activation of cyclic AMP-dependent protein kinase and inhibition of contraction of rat vas deferens by cyclic AMP analogs; Mol. Pharmacol., 39 233 4) Imamura et al. (1998), Differential expression of dystrophin isoforms and utrophin during dibutyryl-cAMP-induced morphological differentiation of rat brain astrocytes; Proc. Natl. Acad. Sci. USA, 95 6139 5) Xia et al. (2016), Transcriptional comparison of human induced and primary midbrain dopaminergic neurons; Sci. Rep., 6 20270 Antibody Specification Alternate Names Bucladesine Na Protein Specification Purity >98% - Reviews
| Bioassays Specification | |
| Bio-Activity | PKA activator |
| Chemical Name | N6,O2'-Dibutyryl adenosine 3',5'-cyclic monophosphate sodium salt |
| Function / Pharmacology | Cell-permeable cAMP analog which mimics the effect of endogenous cAMP when applied to cells.1 Activates PKA.2,3 Induces morphological differentiation of astrocytes.4 Promotes differentiation of dopaminergic neurons from hPSCs (in cocktails with other agents).5 |
| CAS# | 16980-89-5 |
| MW | 491.4 |
| Molecular Formula | C18H23N5O8P • Na |
| Solubility | Soluble in DMSO (50 mg/ml); water (50 mg/ml) |
| Supplied | powder |
| Storage as supplied | -20°C |
| Ship temp | Blue ice |
| References | 1) Bartsch et al. (2003), Bioactivatable, membrane-permeant analogs of cyclic nucleotides as biological tools for growth control of C6 glioma cells; Biol. Chem., 384 1321 2) Carranza et al. (1998), Protein kinase A induces recruitment of active Na+,K+-ATPase units to the plasma membrane of rat proximal convoluted tubule cells; J. Physiol., 15 511 3) Hei et al. (1991), Lack of correlation between activation of cyclic AMP-dependent protein kinase and inhibition of contraction of rat vas deferens by cyclic AMP analogs; Mol. Pharmacol., 39 233 4) Imamura et al. (1998), Differential expression of dystrophin isoforms and utrophin during dibutyryl-cAMP-induced morphological differentiation of rat brain astrocytes; Proc. Natl. Acad. Sci. USA, 95 6139 5) Xia et al. (2016), Transcriptional comparison of human induced and primary midbrain dopaminergic neurons; Sci. Rep., 6 20270 |
| Antibody Specification | |
| Alternate Names | Bucladesine Na |
| Protein Specification | |
| Purity | >98% |