| Catalog | Description | Size | Price (USD) | Qty |
|---|---|---|---|---|
| GBM-2825-5MG | DMAPT | 5mg | $105.00 | |
| GBM-2825-25MG | DMAPT | 25mg | $368.00 |
| Bioassays Specification | |
| Bio-Activity | NFkB inhibitor |
| Chemical Name | Dimethylamino-parthenolide |
| Function / Pharmacology | A water soluble analog of the natural plant product parthenolide which suppresses in vivo tumor growth of two tobacco-associated neoplasms, lung and bladder cancer. It inhibits NFB and stimulates the formation of reactive oxygen species which induced the activation of JNK1. In non-small cell lung cancers it inhibits NFB and DNA double-strand break repair2. |
| CAS# | 870677-05-7 |
| MW | 293.41 |
| Molecular Formula | C17H27NO3 |
| Solubility | Soluble in DMSO, Ethyl acetate, or Ethanol. |
| Supplied | powder |
| Storage as supplied | -20°C |
| Ship temp | Ambient |
| References | 1) Shanmugam et al. (2011), A water soluble parthenolide analog suppresses in vivo tumor growth of two tobacco-associated cancers, lung and bladder cancer, by targeting NFkB and generating reactive oxygen species; Int. J. Cancer, 128 2481 2) Estrabrook et al. (2011), Inhibition of NF-kB and DNA double-strand break repair by DMAPT sensitizes non-small-cell lung cancers to X-rays; Free Radic. Biol. Med., 51 2249 |
| Protein Specification | |
| Purity | >99% |
| Bioassays Specification | |
| Bio-Activity | NFkB inhibitor |
| Chemical Name | Dimethylamino-parthenolide |
| Function / Pharmacology | A water soluble analog of the natural plant product parthenolide which suppresses in vivo tumor growth of two tobacco-associated neoplasms, lung and bladder cancer. It inhibits NFB and stimulates the formation of reactive oxygen species which induced the activation of JNK1. In non-small cell lung cancers it inhibits NFB and DNA double-strand break repair2. |
| CAS# | 870677-05-7 |
| MW | 293.41 |
| Molecular Formula | C17H27NO3 |
| Solubility | Soluble in DMSO, Ethyl acetate, or Ethanol. |
| Supplied | powder |
| Storage as supplied | -20°C |
| Ship temp | Ambient |
| References | 1) Shanmugam et al. (2011), A water soluble parthenolide analog suppresses in vivo tumor growth of two tobacco-associated cancers, lung and bladder cancer, by targeting NFkB and generating reactive oxygen species; Int. J. Cancer, 128 2481 2) Estrabrook et al. (2011), Inhibition of NF-kB and DNA double-strand break repair by DMAPT sensitizes non-small-cell lung cancers to X-rays; Free Radic. Biol. Med., 51 2249 |
| Protein Specification | |
| Purity | >99% |
