| Catalog | Description | Size | Price (USD) | Qty |
|---|---|---|---|---|
| GBM-3148-5MG | NSC59984 | 5mg | $126.00 | |
| GBM-3148-25MG | NSC59984 | 25mg | $420.00 |
| Bioassays Specification | |
| Bio-Activity | p53 activator |
| Chemical Name | (E)-1-(4-Methylpiperazin-1-yl)-3-(5-nitrofuran-2-yl)prop-2-en-1-one |
| Function / Pharmacology | p53 activator. Restores wild-type p53 signaling and depletes mutant p53 gain of function. Induces mutant p53 protein degradation via MDM2 and ubiquitin-proteasome pathway. Induces p73-dependent cell death in cancer cells without toxicity toward normal cells.1 Inhibition of p53-MDM2 interaction remains a viable strategy for cancer therapeutic development.2,3 |
| CAS# | 803647-40-7 |
| MW | 265.27 |
| Molecular Formula | C12H15N3O4 |
| Solubility | Soluble in DMSO (up to 20 mg/ml) |
| Supplied | powder |
| Storage as supplied | -20°C |
| Ship temp | Ambient |
| References | 1) Zhang et al. (2015), Small-Molecule NSC59984 Restores p53 Pathway Signaling and Antitumor effects against Colorectal Cancer via p73 Activation and Degradation of Mutant p53; Cancer Res., 75 3842 2) Ferraiuolo et al. (2016), Oncogenic Intra-p53 Family Member Interactions in Human Cancers; Front. Oncol., 6 77 3) Hong et al. (2014), Targeting tumor suppressor p53 for cancer therapy: strategies, challenges and opportunities; Curr. Drug Targets, 15 80 |
| Protein Specification | |
| Purity | >98% |
| Bioassays Specification | |
| Bio-Activity | p53 activator |
| Chemical Name | (E)-1-(4-Methylpiperazin-1-yl)-3-(5-nitrofuran-2-yl)prop-2-en-1-one |
| Function / Pharmacology | p53 activator. Restores wild-type p53 signaling and depletes mutant p53 gain of function. Induces mutant p53 protein degradation via MDM2 and ubiquitin-proteasome pathway. Induces p73-dependent cell death in cancer cells without toxicity toward normal cells.1 Inhibition of p53-MDM2 interaction remains a viable strategy for cancer therapeutic development.2,3 |
| CAS# | 803647-40-7 |
| MW | 265.27 |
| Molecular Formula | C12H15N3O4 |
| Solubility | Soluble in DMSO (up to 20 mg/ml) |
| Supplied | powder |
| Storage as supplied | -20°C |
| Ship temp | Ambient |
| References | 1) Zhang et al. (2015), Small-Molecule NSC59984 Restores p53 Pathway Signaling and Antitumor effects against Colorectal Cancer via p73 Activation and Degradation of Mutant p53; Cancer Res., 75 3842 2) Ferraiuolo et al. (2016), Oncogenic Intra-p53 Family Member Interactions in Human Cancers; Front. Oncol., 6 77 3) Hong et al. (2014), Targeting tumor suppressor p53 for cancer therapy: strategies, challenges and opportunities; Curr. Drug Targets, 15 80 |
| Protein Specification | |
| Purity | >98% |
