| Catalog | Description | Size | Price (USD) | Qty |
|---|---|---|---|---|
| GBM-3346-5MG | CK-666 | 5mg | $137.00 | |
| GBM-3346-25MG | CK-666 | 25mg | $504.00 |
| Bioassays Specification | |
| Bio-Activity | ARP2/3 inhibitor |
| Chemical Name | 2-Fluoro-N-[2-methyl-1H-indol-3-yl)ethyl]benzamide |
| Function / Pharmacology | A potent, selective and reversible inhibitor of ARP2/3 complex (actin related proteins 2 and 3) with an IC50 = 4 µM for human ARP2/3.1 Blocks actin nucleation and radically alters lamellipodial actin architecture, suspended cell shape and the cell spreading process.2 CK-666 attenuates BBB dysfunction induced by methamphetamine3. It is an important new tool for studying actin assembly and the diverse range of actin-related processes in normal4 and pathophysiology5. |
| CAS# | 442633-00-3 |
| MW | 296.34 |
| Molecular Formula | C18H17FN2O |
| Solubility | Soluble in DMSO (up to 45 mg/ml) or in Ethanol (up to 30 mg/ml). |
| Supplied | powder |
| Storage as supplied | -20°C |
| Ship temp | Ambient |
| References | 1) Nolan et al. (2009), Characterization of two classes of small molecule inhibitors of Arp2/3 complex; Nature, 460 1031 2) Henson et al. (2015), Arp2/3 complex inhibition radically alters lamellipodial actin architecture, suspended cell shape, and the cell spreading process; Mol. Boil. Cell, 26 887 3) Park et al. (2013), Methamphetamine-induced occluding endocytosis is mediated by the Arp2/3 complex-regulated actin rearrangement; J. Biol. Chem., 288 33324 4) Sun et al. (2013), Actin nucleator Arp2/3 complex is essential for mouse preimplantation embryo development; Reprod. Fertil. Dev., 25 617 5) Efremov et al. (2015), Distinct impact of targeted actin cytoskeleton reorganization on mechanical properties of normal and malignant cells; Biochim. Biophys. Acta,, 1853 (11PtB) 3117 |
| Protein Specification | |
| Purity | >98% |
| Bioassays Specification | |
| Bio-Activity | ARP2/3 inhibitor |
| Chemical Name | 2-Fluoro-N-[2-methyl-1H-indol-3-yl)ethyl]benzamide |
| Function / Pharmacology | A potent, selective and reversible inhibitor of ARP2/3 complex (actin related proteins 2 and 3) with an IC50 = 4 µM for human ARP2/3.1 Blocks actin nucleation and radically alters lamellipodial actin architecture, suspended cell shape and the cell spreading process.2 CK-666 attenuates BBB dysfunction induced by methamphetamine3. It is an important new tool for studying actin assembly and the diverse range of actin-related processes in normal4 and pathophysiology5. |
| CAS# | 442633-00-3 |
| MW | 296.34 |
| Molecular Formula | C18H17FN2O |
| Solubility | Soluble in DMSO (up to 45 mg/ml) or in Ethanol (up to 30 mg/ml). |
| Supplied | powder |
| Storage as supplied | -20°C |
| Ship temp | Ambient |
| References | 1) Nolan et al. (2009), Characterization of two classes of small molecule inhibitors of Arp2/3 complex; Nature, 460 1031 2) Henson et al. (2015), Arp2/3 complex inhibition radically alters lamellipodial actin architecture, suspended cell shape, and the cell spreading process; Mol. Boil. Cell, 26 887 3) Park et al. (2013), Methamphetamine-induced occluding endocytosis is mediated by the Arp2/3 complex-regulated actin rearrangement; J. Biol. Chem., 288 33324 4) Sun et al. (2013), Actin nucleator Arp2/3 complex is essential for mouse preimplantation embryo development; Reprod. Fertil. Dev., 25 617 5) Efremov et al. (2015), Distinct impact of targeted actin cytoskeleton reorganization on mechanical properties of normal and malignant cells; Biochim. Biophys. Acta,, 1853 (11PtB) 3117 |
| Protein Specification | |
| Purity | >98% |
