| Catalog | Description | Size | Price (USD) | Qty |
|---|---|---|---|---|
| GBM-3816-5MG | Guggulsterone (Z-) | 5mg | $160.00 | |
| GBM-3816-25MG | Guggulsterone (Z-) | 25mg | $630.00 |
| Bioassays Specification | |
| Bio-Activity | FXR antagonist |
| Chemical Name | (Z)-Pregna-4,17(20)-diene-3,16-dione |
| Function / Pharmacology | A natural steroid from Commiphora mukul extract (guggulipid) which lowers cholesterol and acts as an FXR antagonist.1 Attenuates astrocyte-mediated neuroinflam-mation.2 Induces differentiation of pluripotent stem cells to dopaminergic neurons.3 Produces antidepressant-like effects via activation of the BDNF signaling pathway in mouse models.4 |
| CAS# | 39025-23-5 |
| MW | 312.45 |
| Molecular Formula | C21H28O2 |
| Solubility | Soluble in DMSO (up to 6 mg/ml with warming) or in Ethanol (up to 3 mg/ml with warming) |
| Supplied | powder |
| Storage as supplied | -20°C |
| Ship temp | Ambient |
| References | 1) Urizar et al. (2002), A Natural Product That Lowers Cholesterol as an Antagonist Ligand for FXR; Science, 296 1703 2) Liu et al. (2018), Z-guggulsterone attenuates astrocytes-mediated neuroinflammation after ischemia by inhibiting toll-like receptor 4 pathway; J. Neurochem., 147 803 3) Agbay et al. (2018), Guggulsterone-releasing Microspheres Direct the Differentiation of Human Induced Pluripotent Stem Cells Into Neural Phenotypes; Biomed. Mater., 13 034104 4) Liu et al. (2017), Z-Guggulsterone Produces Antidepressant-Like Effects in Mice through Activation of the BDNF Signaling Pathway; Int. J. Neuropsychopharmacol., 20 485 |
| Protein Specification | |
| Purity | >98% |
| Bioassays Specification | |
| Bio-Activity | FXR antagonist |
| Chemical Name | (Z)-Pregna-4,17(20)-diene-3,16-dione |
| Function / Pharmacology | A natural steroid from Commiphora mukul extract (guggulipid) which lowers cholesterol and acts as an FXR antagonist.1 Attenuates astrocyte-mediated neuroinflam-mation.2 Induces differentiation of pluripotent stem cells to dopaminergic neurons.3 Produces antidepressant-like effects via activation of the BDNF signaling pathway in mouse models.4 |
| CAS# | 39025-23-5 |
| MW | 312.45 |
| Molecular Formula | C21H28O2 |
| Solubility | Soluble in DMSO (up to 6 mg/ml with warming) or in Ethanol (up to 3 mg/ml with warming) |
| Supplied | powder |
| Storage as supplied | -20°C |
| Ship temp | Ambient |
| References | 1) Urizar et al. (2002), A Natural Product That Lowers Cholesterol as an Antagonist Ligand for FXR; Science, 296 1703 2) Liu et al. (2018), Z-guggulsterone attenuates astrocytes-mediated neuroinflammation after ischemia by inhibiting toll-like receptor 4 pathway; J. Neurochem., 147 803 3) Agbay et al. (2018), Guggulsterone-releasing Microspheres Direct the Differentiation of Human Induced Pluripotent Stem Cells Into Neural Phenotypes; Biomed. Mater., 13 034104 4) Liu et al. (2017), Z-Guggulsterone Produces Antidepressant-Like Effects in Mice through Activation of the BDNF Signaling Pathway; Int. J. Neuropsychopharmacol., 20 485 |
| Protein Specification | |
| Purity | >98% |
