| Catalog | Description | Size | Price (USD) | Qty |
|---|---|---|---|---|
| GBM-3980-5MG | BAY-1797 | 5mg | $158.00 | |
| GBM-3980-25MG | BAY-1797 | 25mg | $683.00 |
| Bioassays Specification | |
| Bio-Activity | P2X4 antagonist (selective) |
| Chemical Name | N-[4-(3-Chlorophenoxy)-3-sulfamoylphenyl]-2-phenylacetamide |
| Function / Pharmacology | Selective P2X4 receptor antagonist (IC50 = 211 nM HEK cellular assay; P2X4 calcium influx based assays – hIC50 = 108 nM, mIC50 = 112 nM, rIC50 = 233 nM).1 Displays antinociceptive and anti-inflammatory effects in mouse CFA inflammatory pain models. |
| CAS# | 2055602-83-8 |
| MW | 416.9 |
| Molecular Formula | C20H17ClN2O4S |
| Solubility | Soluble in DMSO (up to 25 mg/ml) |
| Supplied | powder |
| Storage as supplied | -20°C |
| Ship temp | Ambient |
| References | 1. Werner et al. (2019) Discovery and Characterization of the Potent and Selective P2X4 Inhibitor N-[4-(3-Chlorophenoxy)-3-sulfamoylphenyl]-2-phenylacetamide (BAY-1797) and Structure-Guided Amelioration of Its CYP3A4 Induction Profile; J. Med. Chem. 62 11194 |
| Protein Specification | |
| Purity | >98% |
| Bioassays Specification | |
| Bio-Activity | P2X4 antagonist (selective) |
| Chemical Name | N-[4-(3-Chlorophenoxy)-3-sulfamoylphenyl]-2-phenylacetamide |
| Function / Pharmacology | Selective P2X4 receptor antagonist (IC50 = 211 nM HEK cellular assay; P2X4 calcium influx based assays – hIC50 = 108 nM, mIC50 = 112 nM, rIC50 = 233 nM).1 Displays antinociceptive and anti-inflammatory effects in mouse CFA inflammatory pain models. |
| CAS# | 2055602-83-8 |
| MW | 416.9 |
| Molecular Formula | C20H17ClN2O4S |
| Solubility | Soluble in DMSO (up to 25 mg/ml) |
| Supplied | powder |
| Storage as supplied | -20°C |
| Ship temp | Ambient |
| References | 1. Werner et al. (2019) Discovery and Characterization of the Potent and Selective P2X4 Inhibitor N-[4-(3-Chlorophenoxy)-3-sulfamoylphenyl]-2-phenylacetamide (BAY-1797) and Structure-Guided Amelioration of Its CYP3A4 Induction Profile; J. Med. Chem. 62 11194 |
| Protein Specification | |
| Purity | >98% |
