Selinexor
Selinexor
Selinexor
| Catalog | Description | Size | Price (USD) | Qty |
|---|---|---|---|---|
| GBM-4011-5MG | Selinexor | 5mg | $137.00 | |
| GBM-4011-25MG | Selinexor | 25mg | $431.00 |
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Description
Inhibitor of the nuclear export receptor CRM1/XPO1
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Specifications
Bioassays Specification Bio-Activity Inhibitor of the nuclear export receptor CRM1/XPO1 Chemical Name (Z)-3-[3-[3,5-Bis(trifluoromethyl)phenyl]-1,2,4-triazol-1-yl]-N’-pyrazin-2-ylprop-2-enehydrazide Function / Pharmacology Selinexor is a first-in-class chemotherapeutic, functioning by binding to Exportin-1 (XPO1, CRM1), a nuclear membrane-associated protein that aids transport of proteins into the cytoplasm1,2. It also helps maintain chromosome structure3. Inhibition of these functions in cancer cells results in sensitization to DNA damaging agents, cell cycle arrest, and apoptosis4,5. For example, it suppresses growth of T-cell acute lymphoblastic leukemia (T-ALL) cells (IC50 = 34-203 nM)6, and pancreatic cancer cells (IC50 ~ 150 nM)7. Currently in clinical trials for COVID-19 because of its ability to reduce inflammation8. CAS# 1393477-72-9 MW 443.3 Molecular Formula C17H11F6N7O Solubility Soluble in DMSO (up to at least 25 mg/ml) or in Ethanol (up to at least 25 mg/ml) Supplied powder Storage as supplied -20°C Ship temp Ambient References 1. A Degterev et al. Nat. Chem. Biol. 2005 1:112 2. X Dong et al. Nature 2009 458:1136 3. Y Adachi & M Yanagida J. Cell Biol. 1989 108:1195 4. T Kashyap et al. Oncotarget 2018 9:30773 5. HY Fung & YM Chook Semin. Cancer Biol. 2018 9:30773 6. J Etchin et al. Br. J. Haematol. 2013 161:117 7. AS Azmi et al. Gastroenterology 2013 144:447 8. J Taylor et al. Lancet Haematol. 2020 7: e566 Antibody Specification Alternate Names KPT-330 Protein Specification Purity >98% - Reviews
| Bioassays Specification | |
| Bio-Activity | Inhibitor of the nuclear export receptor CRM1/XPO1 |
| Chemical Name | (Z)-3-[3-[3,5-Bis(trifluoromethyl)phenyl]-1,2,4-triazol-1-yl]-N’-pyrazin-2-ylprop-2-enehydrazide |
| Function / Pharmacology | Selinexor is a first-in-class chemotherapeutic, functioning by binding to Exportin-1 (XPO1, CRM1), a nuclear membrane-associated protein that aids transport of proteins into the cytoplasm1,2. It also helps maintain chromosome structure3. Inhibition of these functions in cancer cells results in sensitization to DNA damaging agents, cell cycle arrest, and apoptosis4,5. For example, it suppresses growth of T-cell acute lymphoblastic leukemia (T-ALL) cells (IC50 = 34-203 nM)6, and pancreatic cancer cells (IC50 ~ 150 nM)7. Currently in clinical trials for COVID-19 because of its ability to reduce inflammation8. |
| CAS# | 1393477-72-9 |
| MW | 443.3 |
| Molecular Formula | C17H11F6N7O |
| Solubility | Soluble in DMSO (up to at least 25 mg/ml) or in Ethanol (up to at least 25 mg/ml) |
| Supplied | powder |
| Storage as supplied | -20°C |
| Ship temp | Ambient |
| References | 1. A Degterev et al. Nat. Chem. Biol. 2005 1:112 2. X Dong et al. Nature 2009 458:1136 3. Y Adachi & M Yanagida J. Cell Biol. 1989 108:1195 4. T Kashyap et al. Oncotarget 2018 9:30773 5. HY Fung & YM Chook Semin. Cancer Biol. 2018 9:30773 6. J Etchin et al. Br. J. Haematol. 2013 161:117 7. AS Azmi et al. Gastroenterology 2013 144:447 8. J Taylor et al. Lancet Haematol. 2020 7: e566 |
| Antibody Specification | |
| Alternate Names | KPT-330 |
| Protein Specification | |
| Purity | >98% |