| Catalog | Description | Size | Price (USD) | Qty |
|---|---|---|---|---|
| GBM-4016-5MG | GSK6853 | 5mg | $137.00 | |
| GBM-4016-25MG | GSK6853 | 25mg | $525.00 |
| Bioassays Specification | |
| Bio-Activity | BRPF1 inhibitor |
| Chemical Name | N-[1,3-Dimethyl-6-[(2R)-2-methylpiperazin-1-yl]-2-oxobenzimidazol-5-yl]-2-methoxybenzamide |
| Function / Pharmacology | Very potent (pIC50 = 8.6 vs full length protein, 7.7 in cellular assays) inhibitor of Bromodomain and PHD Finger-containing 1 (BRPF1). It displayed >1600-fold selectivity over other bromodomains. |
| CAS# | 1910124-24-1 |
| MW | 409.49 |
| Molecular Formula | C22H27N5O3 |
| Solubility | Soluble in DMSO (up to at least 25 mg/ml) or in Ethanol (25 mg/ml) |
| Supplied | powder |
| Storage as supplied | -20°C |
| Ship temp | Ambient |
| References | 1) Bamborough et al. (2016), GSK6853, a Chemical Probe for Inhibition of the BRPF1 Bromodomain; ACS Med.Chem. Lett. 7 552 |
| Protein Specification | |
| Purity | >98% |
| Bioassays Specification | |
| Bio-Activity | BRPF1 inhibitor |
| Chemical Name | N-[1,3-Dimethyl-6-[(2R)-2-methylpiperazin-1-yl]-2-oxobenzimidazol-5-yl]-2-methoxybenzamide |
| Function / Pharmacology | Very potent (pIC50 = 8.6 vs full length protein, 7.7 in cellular assays) inhibitor of Bromodomain and PHD Finger-containing 1 (BRPF1). It displayed >1600-fold selectivity over other bromodomains. |
| CAS# | 1910124-24-1 |
| MW | 409.49 |
| Molecular Formula | C22H27N5O3 |
| Solubility | Soluble in DMSO (up to at least 25 mg/ml) or in Ethanol (25 mg/ml) |
| Supplied | powder |
| Storage as supplied | -20°C |
| Ship temp | Ambient |
| References | 1) Bamborough et al. (2016), GSK6853, a Chemical Probe for Inhibition of the BRPF1 Bromodomain; ACS Med.Chem. Lett. 7 552 |
| Protein Specification | |
| Purity | >98% |
