| Catalog | Description | Size | Price (USD) | Qty |
|---|---|---|---|---|
| GBM-4606-5MG | Rbin-1 | 5mg | $105.00 | |
| GBM-4606-25MG | Rbin-1 | 25mg | $368.00 |
| Bioassays Specification | |
| Bio-Activity | Eukaryotic ribosome assembly inhibitor |
| Chemical Name | 3-[(2-Methyl-2-propen-1-yl)sulfanyl]-5H-[1,2,4]triazino[5,6-b]indole |
| Function / Pharmacology | Rbin-1 is potent (GI50 = 136 nM) and reversible inhibitor of eukaryotic ribosome assembly. The biochemical target of Rbin-1 is Midasin (Mdn1), an essential AAA+ protein. Blocking of Mdn1 by Rbin-1 inhibits the processing of pre-60S particles, important pre-ribosomal subunits produced in the nucleolus. |
| CAS# | 328023-11-6 |
| MW | 256.33 |
| Molecular Formula | C13H12N4S |
| Solubility | Soluble in DMSO (up to at least 25 mg/ml) |
| Supplied | powder |
| Storage as supplied | -20°C |
| Ship temp | Ambient |
| References | 1) Kawashime et al. (2016), Potent, Reversible, and Specific Chemical Inhibitors of Eukaryotic Ribosome Biogenesis; Cell 167 512 |
| Protein Specification | |
| Purity | >98% |
| Bioassays Specification | |
| Bio-Activity | Eukaryotic ribosome assembly inhibitor |
| Chemical Name | 3-[(2-Methyl-2-propen-1-yl)sulfanyl]-5H-[1,2,4]triazino[5,6-b]indole |
| Function / Pharmacology | Rbin-1 is potent (GI50 = 136 nM) and reversible inhibitor of eukaryotic ribosome assembly. The biochemical target of Rbin-1 is Midasin (Mdn1), an essential AAA+ protein. Blocking of Mdn1 by Rbin-1 inhibits the processing of pre-60S particles, important pre-ribosomal subunits produced in the nucleolus. |
| CAS# | 328023-11-6 |
| MW | 256.33 |
| Molecular Formula | C13H12N4S |
| Solubility | Soluble in DMSO (up to at least 25 mg/ml) |
| Supplied | powder |
| Storage as supplied | -20°C |
| Ship temp | Ambient |
| References | 1) Kawashime et al. (2016), Potent, Reversible, and Specific Chemical Inhibitors of Eukaryotic Ribosome Biogenesis; Cell 167 512 |
| Protein Specification | |
| Purity | >98% |
