| Catalog | Description | Size | Price (USD) | Qty |
|---|---|---|---|---|
| GBM-5062-5MG | PSB-CB5 | 5mg | $158.00 | |
| GBM-5062-25MG | PSB-CB5 | 25mg | $630.00 |
| Bioassays Specification | |
| Bio-Activity | GPR18 antagonist |
| Chemical Name | (2Z)-2[[3-[(4-Chlorophenyl)methoxy]phenyl]methylene]-6,7-dihydro-5H-imidazo[2,1-b][1,3]thiazin-3(2H)-one |
| Function / Pharmacology | A potent and selective GPR18 antagonist (IC50 = 0.279 µM) exhibiting >36-fold selectivity against GPR55 and CB1 and 14-fold selectivity against CB2.1 Inhibits N-arachidonylglycine-induced acrosomal exocytosis in human spermatozoa indicating that GPR18 may be involved in physiological processes of human spermatozoa.2 |
| CAS# | 1627710-30-8 |
| MW | 384.88 |
| Molecular Formula | C20H17ClN2O2S |
| Solubility | Soluble in DMSO (up to 25 mg/ml) |
| Supplied | powder |
| Storage as supplied | -20°C |
| Ship temp | Ambient |
| References | 1) Rempel et al. (2014), Bicyclic imidazole-4-one serivatives: a new class of antagonists for the orphan G protein-coupled receptors GPR18 and GPR55; Med. Chem. Comm., 5 632 2) Flegel et al. (2016), Characterization of Non-Olfactory GPCRs in Human Sperm With a Focus on GPR18; Sci. Rep., 6 32255 |
| Antibody Specification | |
| Alternate Names | CID-85469571 |
| Protein Specification | |
| Purity | >98% |
| Bioassays Specification | |
| Bio-Activity | GPR18 antagonist |
| Chemical Name | (2Z)-2[[3-[(4-Chlorophenyl)methoxy]phenyl]methylene]-6,7-dihydro-5H-imidazo[2,1-b][1,3]thiazin-3(2H)-one |
| Function / Pharmacology | A potent and selective GPR18 antagonist (IC50 = 0.279 µM) exhibiting >36-fold selectivity against GPR55 and CB1 and 14-fold selectivity against CB2.1 Inhibits N-arachidonylglycine-induced acrosomal exocytosis in human spermatozoa indicating that GPR18 may be involved in physiological processes of human spermatozoa.2 |
| CAS# | 1627710-30-8 |
| MW | 384.88 |
| Molecular Formula | C20H17ClN2O2S |
| Solubility | Soluble in DMSO (up to 25 mg/ml) |
| Supplied | powder |
| Storage as supplied | -20°C |
| Ship temp | Ambient |
| References | 1) Rempel et al. (2014), Bicyclic imidazole-4-one serivatives: a new class of antagonists for the orphan G protein-coupled receptors GPR18 and GPR55; Med. Chem. Comm., 5 632 2) Flegel et al. (2016), Characterization of Non-Olfactory GPCRs in Human Sperm With a Focus on GPR18; Sci. Rep., 6 32255 |
| Antibody Specification | |
| Alternate Names | CID-85469571 |
| Protein Specification | |
| Purity | >98% |
