| Catalog | Description | Size | Price (USD) | Qty |
|---|---|---|---|---|
| GBM-5635-100UG | Calphostin C | 100ug | $290.00 | |
| GBM-5635-500UG | Calphostin C | 500ug | $1,407.00 |
| Bioassays Specification | |
| Bio-Activity | Protein Kinase C inhibitor |
| Chemical Name | Fermentation product from Cladisporium cladosporioides |
| Function / Pharmacology | A potent and specific inhibitor of protein kinase C (PKC, IC50 = 50 nM)1. Inhibition of PKC is light dependent2 and is competitive with the diacylglycerol / phorbol ester binding site1. Calphostin C competes with the diacylglycerol / phorbol ester binding site in other proteins such as Munc13-13. Reverses oxycodone-induced tolerance to respiratory depression4. |
| CAS# | 121263-19-2 |
| MW | 790.8 |
| Molecular Formula | C44H38O14 |
| Solubility | Soluble in DMSO (10 mg/ml) |
| Supplied | powder |
| Storage as supplied | -20°C |
| Ship temp | Ambient |
| References | 1. E Kobayashi et al. Biochem. Biophys. Res. Commun. 1989 159:548 2. RF Bruns et al. Biochem. Biophys. Res. Commun. 1991 176:288 3. A Betz et al. Neuron 1998 21:123 4. R Hill et al. Br. J. Pharmacol. 2018 175:2492 |
| Antibody Specification | |
| Alternate Names | UCN-1028C; PKF115-584 |
| Protein Specification | |
| Purity | >95% |
| Bioassays Specification | |
| Bio-Activity | Protein Kinase C inhibitor |
| Chemical Name | Fermentation product from Cladisporium cladosporioides |
| Function / Pharmacology | A potent and specific inhibitor of protein kinase C (PKC, IC50 = 50 nM)1. Inhibition of PKC is light dependent2 and is competitive with the diacylglycerol / phorbol ester binding site1. Calphostin C competes with the diacylglycerol / phorbol ester binding site in other proteins such as Munc13-13. Reverses oxycodone-induced tolerance to respiratory depression4. |
| CAS# | 121263-19-2 |
| MW | 790.8 |
| Molecular Formula | C44H38O14 |
| Solubility | Soluble in DMSO (10 mg/ml) |
| Supplied | powder |
| Storage as supplied | -20°C |
| Ship temp | Ambient |
| References | 1. E Kobayashi et al. Biochem. Biophys. Res. Commun. 1989 159:548 2. RF Bruns et al. Biochem. Biophys. Res. Commun. 1991 176:288 3. A Betz et al. Neuron 1998 21:123 4. R Hill et al. Br. J. Pharmacol. 2018 175:2492 |
| Antibody Specification | |
| Alternate Names | UCN-1028C; PKF115-584 |
| Protein Specification | |
| Purity | >95% |
