ITA1468
ITA1468
- Catalog: ITA1468
- Gene/Protein: NOTCH2
- Product Description: Immunotag™ Notch 2 (Cleaved-Asp1733) Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet |
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| Target Protein | Notch 2 (Cleaved-Asp1733) |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IHC,IF/ICC,ELISA |
| Recommended Dilution | WB 1:500-1:2000,IHC 1:50-1:200,IF 1:100-1:500 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | A synthesized peptide derived from human Notch 2 (Cleaved-Asp1733) |
| Specificity | Notch 2 (Cleaved-Asp1733) Antibody detects endogenous levels of total Notch 2 (Cleaved-Asp1733) |
| Purification | The antiserum was purified by peptide affinity chromatography. |
| Form | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt |
| Gene Name | NOTCH2 |
| Accession No. | Q04721 |
| Alternate Names | AGS2; hN2; Notch homolog 2; Notch2; |
| Description | Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). Involved in bone remodeling and homeostasis. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation (PubMed:29149593). Positively regulates self-renewal of liver cancer cells (PubMed:25985737). |
| Cell Pathway/ Category | Primary Polyclonal Antibody |
| Protein MW | 110 kDa |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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