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ITA2732

ITA2732-2
ITA2732-1
ITA2732-2
ITA2732-1
ITA2732
  • Gene/Protein: FERMT2
  • Product Description: Immunotag™ Kindlin 2 Antibody
280.0000
Price in reward points: 280

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Immunotag™ Kindlin 2 Antibody
Antibody Specification
Datasheet

Target Protein Kindlin 2
Clonality Polyclonal
Storage/Stability -20°C/1 year
Application WB,IHC
Recommended Dilution WB 1:500-1:2000, IHC 1:50-1:200
Concentration 1 mg/ml
Reactive Species Human,Mouse,Rat
Host Species Rabbit
Immunogen A synthesized peptide derived from human Kindlin 2.
Specificity Kindlin 2 antibody detects endogenous levels of Kindlin 2.
Purification The antiserum was purified by peptide affinity chromatography.
Form Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt
Gene Name FERMT2
Accession No. Q96AC1
Alternate Names FLJ34213; FLJ44462; UNC112; FERM2_HUMAN; Fermitin family homolog 2; Fermt2; KIND2; Kindlin-2; MIG-2; MIG2; Mitogen-inducible gene 2 protein; PH domain-containing family C member 1; Pleckstrin homology domain containing family C (with FERM domain) member 1; Pleckstrin homology domain-containing family C member 1; PLEKHC1; UNC112B;
Description Scaffolding protein that enhances integrin activation mediated by TLN1 and/or TLN2, but activates integrins only weakly by itself. Binds to membranes enriched in phosphoinositides. Enhances integrin-mediated cell adhesion onto the extracellular matrix and cell spreading; this requires both its ability to interact with integrins and with phospholipid membranes. Required for the assembly of focal adhesions. Participates in the connection between extracellular matrix adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and cell shape modulation. Recruits FBLIM1 to focal adhesions. Plays a role in the TGFB1 and integrin signaling pathways. Stabilizes active CTNNB1 and plays a role in the regulation of transcription mediated by CTNNB1 and TCF7L2/TCF4 and in Wnt signaling.
Cell Pathway/ Category Primary Polyclonal Antibody
Protein MW 78 kDa
Usage For Research Use Only! Not for diagnostic or therapeutic procedures.
Material Safety Data Sheet
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