ITA2916
ITA2916
- Catalog: ITA2916
- Gene/Protein: SS18L1
- Product Description: Immunotag™ CREST Antibody
385.0000
Price in reward points: 385
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Antibody Specification | |
Datasheet | |
Target Protein | CREST |
Clonality | Polyclonal |
Storage/Stability | -20°C/1 year |
Application | WB,IHC |
Recommended Dilution | WB 1:500-1:2000, IHC 1:50-1:200 |
Concentration | 1 mg/ml |
Reactive Species | Human,Mouse,Rat |
Host Species | Rabbit |
Immunogen | A synthesized peptide derived from human CREST. |
Specificity | CREST antibody detects endogenous levels of CREST. |
Purification | The antiserum was purified by peptide affinity chromatography. |
Form | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt |
Gene Name | SS18L1 |
Accession No. | O75177 |
Alternate Names | Calcium-responsive transactivator; CREST; CREST_HUMAN; KIAA0693; LP2261; MGC26711; MGC78386; sarcoma translocation gene on chromosome18like1; SS18; SS18-like protein 1; SS18L1; SSXT; synovial sarcoma translocation; synovial sarcoma translocation gene on chromosome 18-like 1; SYT homolog 1; |
Description | Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). |
Cell Pathway/ Category | Primary Polyclonal Antibody |
Protein MW | 50 kDa |
Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |