ITA3608
ITA3608
- Catalog: ITA3608
- Gene/Protein: LRRK2
- Product Description: Immunotag™ LRRK2 Antibody
385.0000
Price in reward points: 385
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Antibody Specification | |
Datasheet | |
Target Protein | LRRK2 |
Clonality | Polyclonal |
Storage/Stability | -20°C/1 year |
Application | WB,ELISA |
Recommended Dilution | WB 1:500-1:2000 |
Concentration | 1 mg/ml |
Reactive Species | Human,Mouse |
Host Species | Rabbit |
Immunogen | A synthesized peptide |
Specificity | LRRK2 antibody detects endogenous levels of total LRRK2 |
Purification | The antiserum was purified by peptide affinity chromatography. |
Form | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
Gene Name | LRRK2 |
Accession No. | Q5S007 |
Alternate Names | augmented in rheumatoid arthritis 17; AURA17; Dardarin; Leucine rich repeat kinase 2; leucine rich repeat serine threonine protein kinase 2; Leucine-rich repeat serine/threonine-protein kinase 2; LRRK 2; LRRK2; LRRK2_HUMAN; PARK 8; PARK8; RIPK7; ROCO 2; ROCO2; |
Description | Positively regulates autophagy through a calcium-dependent activation of the CaMKK/AMPK signaling pathway. The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes. Together with RAB29, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner. Regulates neuronal process morphology in the intact central nervous system (CNS). Plays a role in synaptic vesicle trafficking. Phosphorylates PRDX3. Has GTPase activity. May play a role in the phosphorylation of proteins central to Parkinson disease. |
Cell Pathway/ Category | Primary Polyclonal Antibody |
Protein MW | 286 kDa |
Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |