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ITA4196

ITA4196-3
ITA4196-1
ITA4196-2
ITA4196-3
ITA4196-1
ITA4196-2
ITA4196
  • Catalog: ITA4196
  • Gene/Protein: AAK1
  • Product Description: Immunotag™ AAK1 Antibody
385.0000
Price in reward points: 385

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Immunotag™ AAK1 Antibody
Antibody Specification
Datasheet

Target Protein AAK1
Clonality Polyclonal
Storage/Stability -20°C/1 year
Application WB,IF/ICC,ELISA
Recommended Dilution WB 1:500~1:1000, IF/ICC 1:100-1:500
Concentration 1 mg/ml
Reactive Species Human,Mouse,Rat
Host Species Rabbit
Immunogen A synthesized peptide
Specificity AAK1 Antibody detects endogenous levels of total AAK1
Purification The antiserum was purified by peptide affinity chromatography.
Form Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt
Gene Name AAK1
Accession No. Q2M2I8
Alternate Names AAK 1; Aak1; AAK1_HUMAN; Adaptor associated kinase 1; Adaptor-associated kinase 1; AP2 associated kinase 1; AP2 associated protein kinase 1; AP2-associated protein kinase 1; DKFZp686F03202; DKFZp686K16132; FLJ23712; FLJ25931; FLJ31060; FLJ42882; FLJ45252; KIAA1048; MGC138170; MGC164568; MGC164570;
Description Regulates clathrin-mediated endocytosis by phosphorylating the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2) which ensures high affinity binding of AP-2 to cargo membrane proteins during the initial stages of endocytosis. Isoform 1 and isoform 2 display similar levels of kinase activity towards AP2M1. Regulates phosphorylation of other AP-2 subunits as well as AP-2 localization and AP-2-mediated internalization of ligand complexes. Phosphorylates NUMB and regulates its cellular localization, promoting NUMB localization to endosomes. Binds to and stabilizes the activated form of NOTCH1, increases its localization in endosomes and regulates its transcriptional activity.
Cell Pathway/ Category Primary Polyclonal Antibody
Protein MW 94 KD
Usage For Research Use Only! Not for diagnostic or therapeutic procedures.
Material Safety Data Sheet
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