ITA4803
ITA4803
- Catalog: ITA4803
- Gene/Protein: CBLN1
- Product Description: Immunotag™ CBLN1 Antibody
385.0000
Price in reward points: 385
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Antibody Specification | |
Datasheet | |
Target Protein | CBLN1 |
Clonality | Polyclonal |
Storage/Stability | -20°C/1 year |
Application | WB,IF/ICC,ELISA |
Recommended Dilution | WB 1:500~1:1000, IF/ICC 1:100-1:500 |
Concentration | 1 mg/ml |
Reactive Species | Human,Mouse,Rat |
Host Species | Rabbit |
Immunogen | A synthesized peptide |
Specificity | CBLN1 Antibody detects endogenous levels of total CBLN1 |
Purification | The antiserum was purified by peptide affinity chromatography. |
Form | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt |
Gene Name | CBLN1 |
Accession No. | P23435 |
Alternate Names | [des-Ser1]-cerebellin; CBLN 1; CBLN1; CBLN1_HUMAN; CER; Cerebellin 1; Cerebellin 1 precursor; Cerebellin1; Precerebellin; |
Description | Required for synapse integrity and synaptic plasticity. During cerebellar synapse formation, essential for the matching and maintenance of pre- and post-synaptic elements at parallel fiber-Purkinje cell synapses, the establishment of the proper pattern of climbing fiber-Purkinje cell innervation, and induction of long-term depression at parallel fiber-Purkinje cell synapses. Plays a role as a synaptic organizer that acts bidirectionally on both pre- and post-synaptic components. On the one hand induces accumulation of synaptic vesicles in the pre-synaptic part by binding with NRXN1 and in other hand induces clustering of GRID2 and its associated proteins at the post-synaptic site through association of GRID2. NRXN1-CBLN1-GRID2 complex directly induces parallel fiber protrusions that encapsulate spines of Purkinje cells leading to accumulation of GRID2 and synaptic vesicles. Required for CBLN3 export from the endoplasmic reticulum and secretion (By similarity). NRXN1-CBLN1-GRID2 complex mediates the D-Serine-dependent long term depression signals and AMPA receptor endocytosis (PubMed:27418511). |
Cell Pathway/ Category | Primary Polyclonal Antibody |
Protein MW | 25 KD |
Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |