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ITA4803

ITA4803-2
ITA4803-1
ITA4803-2
ITA4803-1
ITA4803
  • Catalog: ITA4803
  • Gene/Protein: CBLN1
  • Product Description: Immunotag™ CBLN1 Antibody
385.0000
Price in reward points: 385

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Immunotag™ CBLN1 Antibody
Antibody Specification
Datasheet

Target Protein CBLN1
Clonality Polyclonal
Storage/Stability -20°C/1 year
Application WB,IF/ICC,ELISA
Recommended Dilution WB 1:500~1:1000, IF/ICC 1:100-1:500
Concentration 1 mg/ml
Reactive Species Human,Mouse,Rat
Host Species Rabbit
Immunogen A synthesized peptide
Specificity CBLN1 Antibody detects endogenous levels of total CBLN1
Purification The antiserum was purified by peptide affinity chromatography.
Form Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt
Gene Name CBLN1
Accession No. P23435
Alternate Names [des-Ser1]-cerebellin; CBLN 1; CBLN1; CBLN1_HUMAN; CER; Cerebellin 1; Cerebellin 1 precursor; Cerebellin1; Precerebellin;
Description Required for synapse integrity and synaptic plasticity. During cerebellar synapse formation, essential for the matching and maintenance of pre- and post-synaptic elements at parallel fiber-Purkinje cell synapses, the establishment of the proper pattern of climbing fiber-Purkinje cell innervation, and induction of long-term depression at parallel fiber-Purkinje cell synapses. Plays a role as a synaptic organizer that acts bidirectionally on both pre- and post-synaptic components. On the one hand induces accumulation of synaptic vesicles in the pre-synaptic part by binding with NRXN1 and in other hand induces clustering of GRID2 and its associated proteins at the post-synaptic site through association of GRID2. NRXN1-CBLN1-GRID2 complex directly induces parallel fiber protrusions that encapsulate spines of Purkinje cells leading to accumulation of GRID2 and synaptic vesicles. Required for CBLN3 export from the endoplasmic reticulum and secretion (By similarity). NRXN1-CBLN1-GRID2 complex mediates the D-Serine-dependent long term depression signals and AMPA receptor endocytosis (PubMed:27418511).
Cell Pathway/ Category Primary Polyclonal Antibody
Protein MW 25 KD
Usage For Research Use Only! Not for diagnostic or therapeutic procedures.
Material Safety Data Sheet
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