ITA5678
ITA5678
- Catalog: ITA5678
- Gene/Protein: ERI1
- Product Description: Immunotag™ ERI1 Antibody
385.0000
Price in reward points: 385
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Antibody Specification | |
Datasheet | |
Target Protein | ERI1 |
Clonality | Polyclonal |
Storage/Stability | -20°C/1 year |
Application | WB,IF/ICC,ELISA |
Recommended Dilution | WB 1:500~1:1000, IF/ICC 1:100-1:500 |
Concentration | 1 mg/ml |
Reactive Species | Human,Mouse,Rat |
Host Species | Rabbit |
Immunogen | A synthesized peptide |
Specificity | ERI1 Antibody detects endogenous levels of total ERI1 |
Purification | The antiserum was purified by peptide affinity chromatography. |
Form | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt |
Gene Name | ERI1 |
Accession No. | Q8IV48 |
Alternate Names | 3' 5' exonuclease ERI 1; 3' 5' exonuclease ERI1; 3' EXO; 3' exoribonuclease; 3' HEXO; 3' histone mRNA exonuclease 1; 3''-5'' exonuclease eri1; 3''-5'' exoribonuclease 1; 3'EXO; 3'HEXO; ERI 1; Eri 1 homolog; Eri-1 homolog; eri1; Eri1 homolog; ERI1_HUMAN; HEXO; Histone mRNA 3' end specific exonuclease; Histone mRNA 3' end specific exoribonuclease; Histone mRNA 3''-end-specific exoribonuclease; Histone mRNA 3''-exonuclease 1; MGC35395; Protein 3''hExo; THEX 1; THEX1; Three prime histone mRNA exonuclease 1; |
Description | RNA exonuclease that binds to the 3'-end of histone mRNAs and degrades them, suggesting that it plays an essential role in histone mRNA decay after replication. A 2' and 3'-hydroxyl groups at the last nucleotide of the histone 3'-end is required for efficient degradation of RNA substrates. Also able to degrade the 3'-overhangs of short interfering RNAs (siRNAs) in vitro, suggesting a possible role as regulator of RNA interference (RNAi). Requires for binding the 5'-ACCCA-3' sequence present in stem-loop structure. Able to bind other mRNAs. Required for 5.8S rRNA 3'-end processing. Also binds to 5.8s ribosomal RNA. Binds with high affinity to the stem-loop structure of replication-dependent histone pre-mRNAs. |
Cell Pathway/ Category | Primary Polyclonal Antibody |
Protein MW | 40 KD |
Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |