ITA6423
ITA6423
- Catalog: ITA6423
- Gene/Protein: ATP6AP1
- Product Description: Immunotag™ ATP6AP1 Antibody
385.0000
Price in reward points: 385
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Antibody Specification | |
Datasheet | |
Target Protein | ATP6AP1 |
Clonality | Polyclonal |
Storage/Stability | -20°C/1 year |
Application | WB,IHC,ELISA |
Recommended Dilution | WB 1:500-1:2000 IHC 1:50-1:200 |
Concentration | 1 mg/ml |
Reactive Species | Human,Mouse,Rat |
Host Species | Rabbit |
Immunogen | A synthesized peptide derived from human ATP6AP1 |
Specificity | ATP6AP1 Antibody detects endogenous levels of total ATP6AP1 |
Purification | The antiserum was purified by peptide affinity chromatography. |
Form | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt |
Gene Name | ATP6AP1 |
Accession No. | Q15904 |
Alternate Names | 16A; Ac45; ATP6IP1; ATP6S1; ATPase H+ transporting lysosomal (vacuolar proton pump) subunit 1; ATPase H+ transporting lysosomal accessory protein 1; ATPase H+ transporting lysosomal interacting protein 1; CF2; H ATPase subunit; MGC129781; ORF; Protein XAP 3; Protein XAP3; V ATPase Ac45 subunit; V ATPase S1 accessory protein; V ATPase subunit S1; V type proton ATPase subunit S1; Vacuolar ATP synthase subunit S1; Vacuolar proton pump subunit S1; VATPS1; XAP 3; XAP3; |
Description | Accessory subunit of the proton-transporting vacuolar (V)-ATPase protein pump, which is required for luminal acidification of secretory vesicles. Guides the V-type ATPase into specialized subcellular compartments, such as neuroendocrine regulated secretory vesicles or the ruffled border of the osteoclast, thereby regulating its activity. Involved in membrane trafficking and Ca2+-dependent membrane fusion. May play a role in the assembly of the V-type ATPase complex. In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe2+ prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (PubMed:28296633). |
Cell Pathway/ Category | Primary Polyclonal Antibody |
Protein MW | 52kDa |
Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |