ITA6718
ITA6718
- Catalog: ITA6718
- Gene/Protein: CXADR
- Product Description: Immunotag™ CXADR Antibody
385.0000
Price in reward points: 385
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Antibody Specification | |
Datasheet | |
Target Protein | CXADR |
Clonality | Polyclonal |
Storage/Stability | -20°C/1 year |
Application | WB,IHC,IF/ICC,ELISA |
Recommended Dilution | WB 1:500-1:2000, IF/ICC 1:100-1:500, IHC 1:50-1:200 |
Concentration | 1 mg/ml |
Reactive Species | Human,Mouse,Rat |
Host Species | Rabbit |
Immunogen | A synthesized peptide derived from human CXADR |
Specificity | CXADR Antibody detects endogenous levels of total CXADR |
Purification | The antiserum was purified by peptide affinity chromatography. |
Form | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt |
Gene Name | CXADR |
Accession No. | P78310 |
Alternate Names | 46 kD coxsackievirus and adenovirus receptor CAR protein; 46 kD coxsackievirus and adenovirus receptor protein; CAR; CAR4/6; Coxsackie virus and adenovirus receptor; Coxsackie virus B receptor; Coxsackievirus and adenovirus receptor; Coxsackievirus B adenovirus receptor; Coxsackievirus B-adenovirus receptor; CVB3 binding protein; CVB3-binding protein; Cxadr; CXAR_HUMAN; hCAR; HCVADR; |
Description | Component of the epithelial apical junction complex that may function as a homophilic cell adhesion molecule and is essential for tight junction integrity. Also involved in transepithelial migration of leukocytes through adhesive interactions with JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair. |
Cell Pathway/ Category | Primary Polyclonal Antibody |
Protein MW | 40kDa |
Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |