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ITA7101

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ITA7101-1
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ITA7101-1
ITA7101
  • Catalog: ITA7101
  • Gene/Protein: SUMO2
  • Product Description: Immunotag™ SUMO2 Antibody
385.0000
Price in reward points: 385

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Immunotag™ SUMO2 Antibody
Antibody Specification
Datasheet

Target Protein SUMO2
Clonality Polyclonal
Storage/Stability -20°C/1 year
Application WB,IHC,ELISA
Recommended Dilution WB 1:500-1:2000 IHC 1:50-1:200
Concentration 1 mg/ml
Reactive Species Human,Mouse,Rat
Host Species Rabbit
Immunogen A synthesized peptide derived from human SUMO2
Specificity SUMO2 Antibody detects endogenous levels of total SUMO2
Purification The antiserum was purified by peptide affinity chromatography.
Form Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt
Gene Name SUMO2
Accession No. P61956
Alternate Names HSMT3; MGC117191; OTTHUMP00000115275; OTTHUMP00000115276; OTTHUMP00000115277; Sentrin 2; Small ubiquitin like modifier 2; Small ubiquitin related modifier 2; small ubiquitin-like modifier 3; small ubiquitin-related modifier 3; SMT3 homolog 1; SMT3 homolog 2; SMT3 suppressor of mif two 3 homolog 1; SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae); SMT3 suppressor of mif two 3 homolog 2; SMT3 suppressor of mif two 3 homolog 3 (S. cerevisiae); SMT3 suppressor of mif two 3 homolog 3; SMT3A; SMT3B; SMT3H1; SMT3H2; Sumo2; Sumo3; Ubiquitin like protein SMT3A; Ubiquitin like protein SMT3B;
Description Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2, CBX4 or ZNF451 (PubMed:26524494). This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins (PubMed:18408734, PubMed:18538659, PubMed:21965678, PubMed:9556629). Plays a role in the regulation of sumoylation status of SETX (PubMed:24105744).
Cell Pathway/ Category Primary Polyclonal Antibody
Protein MW 11kDa
Usage For Research Use Only! Not for diagnostic or therapeutic procedures.
Material Safety Data Sheet
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