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ITA7111

ITA7111-2
ITA7111-1
ITA7111-2
ITA7111-1
  • Gene/Protein: PRNP
  • Product Description: Immunotag™ PRNP Antibody
  • 280.0000
    Price in reward points: 280

    Available Options

ITA7111

Immunotag™ PRNP Antibody
Antibody Specification
Datasheet

Target Protein PRNP
Clonality Polyclonal
Storage/Stability -20°C/1 year
Application WB,IHC,ELISA
Recommended Dilution WB 1:500-1:2000 IHC 1:50-1:200
Concentration 1 mg/ml
Reactive Species Human,Mouse,Rat
Host Species Rabbit
Immunogen A synthesized peptide derived from human PRNP
Specificity PRNP Antibody detects endogenous levels of total PRNP
Purification The antiserum was purified by peptide affinity chromatography.
Form Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt
Gene Name PRNP
Accession No. P04156
Alternate Names Alternative prion protein; major prion protein; AltPrP; ASCR; CD230; CD230 antigen; CJD; GSS; KURU; Major prion protein; p27 30; PRIO_HUMAN; Prion protein; Prion related protein; PRIP; PRNP; PrP; PrP27 30; PrP27-30; PrP33-35C; PrPC; PrPSc; Sinc;
Description Its primary physiological function is unclear. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May promote myelin homeostasis through acting as an agonist for ADGRG6 receptor. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro) (By similarity). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu2+ or ZN2+ for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity).
Cell Pathway/ Category Primary Polyclonal Antibody
Protein MW 27kDa
Usage For Research Use Only! Not for diagnostic or therapeutic procedures.
Material Safety Data Sheet
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