ITA7161
ITA7161
- Catalog: ITA7161
- Gene/Protein: PTPN11
- Product Description: Immunotag™ PTPN11 Antibody
385.0000
Price in reward points: 385
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Antibody Specification | |
Datasheet | |
Target Protein | PTPN11 |
Clonality | Polyclonal |
Storage/Stability | -20°C/1 year |
Application | WB,IHC,IF/ICC,ELISA |
Recommended Dilution | WB 1:500-1:1000 IHC 1:50-1:100, IF/ICC 1:100-1:500 |
Concentration | 1 mg/ml |
Reactive Species | Human,Mouse,Rat |
Host Species | Rabbit |
Immunogen | Fusion protein of human PTPN11 |
Specificity | PTPN11 Antibody detects endogenous levels of total PTPN11 |
Purification | The antiserum was purified by peptide affinity chromatography. |
Form | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt |
Gene Name | PTPN11 |
Accession No. | Q06124 |
Alternate Names | BPTP3; CFC; JMML; METCDS; MGC14433; NS1; OTTHUMP00000166107; OTTHUMP00000166108; Protein tyrosine phosphatase 2; Protein tyrosine phosphatase 2C; Protein tyrosine phosphatase non receptor type 11; Protein-tyrosine phosphatase 1D; Protein-tyrosine phosphatase 2C; PTN11_HUMAN; PTP-1D; PTP-2C; PTP1D; PTP2C; PTPN11; SAP2; SH-PTP2; SH-PTP3; SH2 domain containing protein tyrosine phosphatase 2; SHP 2; SHP-2; Shp2; SHPTP2; SHPTP3; Syp; Tyrosine-protein phosphatase non-receptor type 11; |
Description | Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Positively regulates MAPK signal transduction pathway (PubMed:28074573). Dephosphorylates GAB1, ARHGAP35 and EGFR (PubMed:28074573). Dephosphorylates ROCK2 at 'Tyr-722' resulting in stimulatation of its RhoA binding activity. Dephosphorylates CDC73 (PubMed:26742426). |
Cell Pathway/ Category | Primary Polyclonal Antibody |
Protein MW | 68kDa |
Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |