menu
Your Cart

ITC0074

ITC0074
ITC0074-2
ITC0074
ITC0074-2
ITC0074
  • Catalog: ITC0074
  • Gene/Protein: SPTAN1
  • Product Description: Immunotag™ Cleaved-Spectrin α II (D1185) Polyclonal Antibody
460.0000
Price in reward points: 460

Available Options

Immunotag™ Cleaved-Spectrin α II (D1185) Polyclonal Antibody
Antibody Specification
Datasheet
Target Protein Spectrin α II (D1185)
Clonality Polyclonal
Storage/Stability -20°C/1 year
Application WB,ELISA
Recommended Dilution Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Concentration 1 mg/ml
Reactive Species Human
Host Species Rabbit
Immunogen The antiserum was produced against synthesized peptide derived from human SPTA2. AA range:1136-1185
Specificity Cleaved-Spectrin α II (D1185) Polyclonal Antibody detects endogenous levels of fragment of activated Spectrin α II protein resulting from cleavage adjacent to D1185.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene Name SPTAN1
Accession No. Q13813 P16546
Alternate Names SPTAN1; NEAS; SPTA2; Spectrin alpha chain; non-erythrocytic 1; Alpha-II spectrin; Fodrin alpha chain; Spectrin, non-erythroid alpha subunit
Description spectrin alpha, non-erythrocytic 1(SPTAN1) Homo sapiens Spectrins are a family of filamentous cytoskeletal proteins that function as essential scaffold proteins that stabilize the plasma membrane and organize intracellular organelles. Spectrins are composed of alpha and beta dimers that associate to form tetramers linked in a head-to-head arrangement. This gene encodes an alpha spectrin that is specifically expressed in nonerythrocytic cells. The encoded protein has been implicated in other cellular functions including DNA repair and cell cycle regulation. Mutations in this gene are the cause of early infantile epileptic encephalopathy-5. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Sep 2010],
Cell Pathway/ Category Tight junction,
Protein Expression Aorta,Brain,Epithelium,Fetal brain,Fetal brain cortex,Fetal liver,L
Subcellular Localization cytosol,cell-cell adherens junction,spectrin,microtubule cytoskeleton,membrane,intracellular membrane-bounded organelle,extracellular exosome,extracellular vesicle,
Protein Function function:Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane.,PTM:Phosphorylation of Tyr-1176 decreases sensitivity to cleavage by calpain in vitro.,similarity:Belongs to the spectrin family.,similarity:Contains 1 SH3 domain.,similarity:Contains 23 spectrin repeats.,similarity:Contains 3 EF-hand domains.,subunit:Like erythrocyte spectrin, the spectrin-like proteins are capable of forming dimers which can further associate to tetramers. Interacts with isoform 1 of ACP1. Interacts with CALM.,
Usage For Research Use Only! Not for diagnostic or therapeutic procedures.
Material Safety Data Sheet
English_US
Danish
Dutch
English_UK
French
German
Spanish
Norwegian
Portuguese
Finnish
Swedish
Polish

Write a review

Note: HTML is not translated!
Bad Good
Captcha

CONNECT WITH US