ITM0019
ITM0019
- Catalog: ITM0019
- Gene/Protein: AKT2
- Product Description: Immunotag™ Akt2 Monoclonal Antibody
504.0000
Price in reward points: 504
| Antibody Specification | |
| Datasheet | 
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| Target Protein | AKT2 |
| Clonality | Monoclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IHC-p,IF,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/200 - 1/1000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Rat,Monkey |
| Host Species | Mouse |
| Immunogen | Purified recombinant fragment of human Akt2 expressed in E Coli |
| Specificity | Akt2 Monoclonal Antibody detects endogenous levels of Akt2 protein. |
| Purification | Affinity purification |
| Form | Ascitic fluid containing 0.03% sodium azide. |
| Gene Name | AKT2 |
| Accession No. | P31751 Q60823 P47197 |
| Alternate Names | AKT2; RAC-beta serine/threonine-protein kinase; Protein kinase Akt-2; Protein kinase B beta; PKB beta; RAC-PK-beta |
| Description | AKT serine/threonine kinase 2(AKT2) Homo sapiens This gene is a putative oncogene encoding a protein belonging to a subfamily of serine/threonine kinases containing SH2-like (Src homology 2-like) domains. The gene was shown to be amplified and overexpressed in 2 of 8 ovarian carcinoma cell lines and 2 of 15 primary ovarian tumors. Overexpression contributes to the malignant phenotype of a subset of human ductal pancreatic cancers. The encoded protein is a general protein kinase capable of phophorylating several known proteins. [provided by RefSeq, Jul 2008], |
| Cell Pathway/ Category | Regulation_Microtubule, Stem cell pathway, T_Cell_Receptor, Regulates Angiogenesis, Insulin Receptor, Toll_Like, ErbB/HER, AMPK, MAPK_ERK_Growth,MAPK_G_Protein, B_Cell_Antigen, Adherens_Junction, PI3K/Akt, mTOR |
| Protein Expression | Blood,Epithelium,Lymph,Pancreas,PCR rescued clones,Placenta, |
| Subcellular Localization | nucleus,nucleoplasm,early endosome,cytosol,plasma membrane,cell cortex,ruffle membrane, |
| Protein Function | catalytic activity:ATP + a protein = ADP + a phosphoprotein.,disease:Alterations of AKT2 may contribute to the pathogenesis of ovarian carcinomas.,enzyme regulation:Two specific sites, one in the kinase domain (Thr-309) and the other in the C-terminal regulatory region (Ser-474), need to be phosphorylated for its full activation.,function:General protein kinase capable of phosphorylating several known proteins.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily.,similarity:Contains 1 AGC-kinase C-terminal domain.,similarity:Contains 1 PH domain.,similarity:Contains 1 protein kinase domain.,subunit:Interacts (via PH domain) with MTCP1, TCL1A AND TCL1B.,tissue specificity:In all human cell types so far analyzed., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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