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ITM0055

  • Gene/Protein: AXL
  • Product Description: Immunotag™ Axl Monoclonal Antibody
  • 368.0000
    Price in reward points: 368

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ITM0055

Immunotag™ Axl Monoclonal Antibody
Antibody Specification
Datasheet
Target Protein Axl
Clonality Monoclonal
Storage/Stability -20°C/1 year
Application WB,IF,ELISA
Recommended Dilution Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.
Concentration 1 mg/ml
Reactive Species Human
Host Species Mouse
Immunogen Purified recombinant extracellular fragment of human Axl fused with hIgGFc tag expressed in HEK293 cell line.
Specificity Axl Monoclonal Antibody detects endogenous levels of Axl protein.
Purification Affinity purification
Form Ascitic fluid containing 0.03% sodium azide.
Gene Name AXL
Accession No. P30530 Q00993
Alternate Names AXL; UFO; Tyrosine-protein kinase receptor UFO; AXL oncogene
Description AXL receptor tyrosine kinase(AXL) Homo sapiens The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. The encoded protein possesses an extracellular domain which is composed of two immunoglobulin-like motifs at the N-terminal, followed by two fibronectin type-III motifs. It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6 (Gas6). This gene may be involved in several cellular functions including growth, migration, aggregation and anti-inflammation in multiple cell types. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013],
Protein Expression Colon tumor,Fibroblast,
Subcellular Localization extracellular space,intracellular,plasma membrane,integral component of plasma membrane,cell surface,integral component of membrane,host cell surface,extracellular exosome,
Protein Function catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,disease:Has transforming potential in patients with chronic myeloproliferative disorder or chronic myelocytic leukemia.,function:May function as a signal transducer between specific cell types of mesodermal origin. In case of filovirus infection, seems to function as a cell entry factor.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. AXL/UFO subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 2 fibronectin type-III domains.,similarity:Contains 2 Ig-like C2-type (immunoglobulin-like) domains.,subunit:Heterodimer and heterotetramer with GAS6.,tissue specificity:Highly expressed in metastatic colon tumors. Expressed in primary colon tumors. Weakly expressed in normal colon tissue.,
Usage For Research Use Only! Not for diagnostic or therapeutic procedures.
Material Safety Data Sheet
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