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ITM0312

ITM0312
  • Catalog: ITM0312
  • Gene/Protein: GPI
  • Product Description: Immunotag™ GPI Monoclonal Antibody
504.0000
Price in reward points: 504

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Immunotag™ GPI Monoclonal Antibody
Antibody Specification
Datasheet
Target Protein GPI
Clonality Monoclonal
Storage/Stability -20°C/1 year
Application WB,IHC-p,IF,ELISA
Recommended Dilution Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/200 - 1/1000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.
Concentration 1 mg/ml
Reactive Species Human
Host Species Mouse
Immunogen Purified recombinant fragment of human GPI expressed in E. Coli.
Specificity GPI Monoclonal Antibody detects endogenous levels of GPI protein.
Purification Affinity purification
Form Ascitic fluid containing 0.03% sodium azide.
Gene Name GPI
Accession No. P06744 P06745
Alternate Names GPI; Glucose-6-phosphate isomerase; GPI; Autocrine motility factor; AMF; Neuroleukin; NLK; Phosphoglucose isomerase; PGI; Phosphohexose isomerase; PHI; Sperm antigen 36; SA-36
Description glucose-6-phosphate isomerase(GPI) Homo sapiens This gene encodes a member of the glucose phosphate isomerase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. In the cytoplasm, the gene product functions as a glycolytic enzyme (glucose-6-phosphate isomerase) that interconverts glucose-6-phosphate and fructose-6-phosphate. Extracellularly, the encoded protein (also referred to as neuroleukin) functions as a neurotrophic factor that promotes survival of skeletal motor neurons and sensory neurons, and as a lymphokine that induces immunoglobulin secretion. The encoded protein is also referred to as autocrine motility factor based on an additional function as a tumor-secreted cytokine and angiogenic factor. Defects in this gene are the cause of nonspherocytic hemolytic anemia and a severe enzyme deficiency can be associated with hydrops fetalis
Cell Pathway/ Category Glycolysis / Gluconeogenesis,Pentose phosphate pathway,Starch and sucrose metabolism,Amino sugar and nucleotide sugar metabolism,
Protein Expression B-cell lymphoma,Brain,Skin,Spleen,Testis,
Subcellular Localization extracellular space,nucleoplasm,cytoplasm,cytosol,plasma membrane,membrane,neuron projection,myelin sheath,ciliary membrane,extracellular exosome,
Protein Function catalytic activity:D-glucose 6-phosphate = D-fructose 6-phosphate.,disease:Defects in GPI are a cause of hereditary nonspherocytic hemolytic anemia (HA) [MIM:172400]. Severe GPI deficiency can be associated with hydrops fetalis, immediate neonatal death and neurological impairment.,function:Besides it's role as a glycolytic enzyme, mammalian GPI can function as a tumor-secreted cytokine and an angiogenic factor (AMF) that stimulates endothelial cell motility. GPI is also a neurotrophic factor (Neuroleukin) for spinal and sensory neurons.,online information:Phosphoglucose isomerase entry,online information:The Singapore human mutation and polymorphism database,pathway:Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4.,PTM:Phosphorylation at Ser-185 by CK2 has been shown to decrease enzymatic activity and may contribute to secretion by a non-classical secretory pathway.,similarity:Belongs to the GPI family.,subunit:Homodimer in the catalytically active form, monomer in the secreted form.,
Usage For Research Use Only! Not for diagnostic or therapeutic procedures.
Material Safety Data Sheet
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