ITM0312
ITM0312
- Catalog: ITM0312
- Gene/Protein: GPI
- Product Description: Immunotag™ GPI Monoclonal Antibody
504.0000
Price in reward points: 504
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Antibody Specification | |
Datasheet | |
Target Protein | GPI |
Clonality | Monoclonal |
Storage/Stability | -20°C/1 year |
Application | WB,IHC-p,IF,ELISA |
Recommended Dilution | Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/200 - 1/1000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications. |
Concentration | 1 mg/ml |
Reactive Species | Human |
Host Species | Mouse |
Immunogen | Purified recombinant fragment of human GPI expressed in E. Coli. |
Specificity | GPI Monoclonal Antibody detects endogenous levels of GPI protein. |
Purification | Affinity purification |
Form | Ascitic fluid containing 0.03% sodium azide. |
Gene Name | GPI |
Accession No. | P06744 P06745 |
Alternate Names | GPI; Glucose-6-phosphate isomerase; GPI; Autocrine motility factor; AMF; Neuroleukin; NLK; Phosphoglucose isomerase; PGI; Phosphohexose isomerase; PHI; Sperm antigen 36; SA-36 |
Description | glucose-6-phosphate isomerase(GPI) Homo sapiens This gene encodes a member of the glucose phosphate isomerase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. In the cytoplasm, the gene product functions as a glycolytic enzyme (glucose-6-phosphate isomerase) that interconverts glucose-6-phosphate and fructose-6-phosphate. Extracellularly, the encoded protein (also referred to as neuroleukin) functions as a neurotrophic factor that promotes survival of skeletal motor neurons and sensory neurons, and as a lymphokine that induces immunoglobulin secretion. The encoded protein is also referred to as autocrine motility factor based on an additional function as a tumor-secreted cytokine and angiogenic factor. Defects in this gene are the cause of nonspherocytic hemolytic anemia and a severe enzyme deficiency can be associated with hydrops fetalis |
Cell Pathway/ Category | Glycolysis / Gluconeogenesis,Pentose phosphate pathway,Starch and sucrose metabolism,Amino sugar and nucleotide sugar metabolism, |
Protein Expression | B-cell lymphoma,Brain,Skin,Spleen,Testis, |
Subcellular Localization | extracellular space,nucleoplasm,cytoplasm,cytosol,plasma membrane,membrane,neuron projection,myelin sheath,ciliary membrane,extracellular exosome, |
Protein Function | catalytic activity:D-glucose 6-phosphate = D-fructose 6-phosphate.,disease:Defects in GPI are a cause of hereditary nonspherocytic hemolytic anemia (HA) [MIM:172400]. Severe GPI deficiency can be associated with hydrops fetalis, immediate neonatal death and neurological impairment.,function:Besides it's role as a glycolytic enzyme, mammalian GPI can function as a tumor-secreted cytokine and an angiogenic factor (AMF) that stimulates endothelial cell motility. GPI is also a neurotrophic factor (Neuroleukin) for spinal and sensory neurons.,online information:Phosphoglucose isomerase entry,online information:The Singapore human mutation and polymorphism database,pathway:Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4.,PTM:Phosphorylation at Ser-185 by CK2 has been shown to decrease enzymatic activity and may contribute to secretion by a non-classical secretory pathway.,similarity:Belongs to the GPI family.,subunit:Homodimer in the catalytically active form, monomer in the secreted form., |
Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |