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ITM0365

ITM0365
  • Catalog: ITM0365
  • Gene/Protein: IL10
  • Product Description: Immunotag™ IL-10 Monoclonal Antibody
504.0000
Price in reward points: 504

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Immunotag™ IL-10 Monoclonal Antibody
Antibody Specification
Datasheet
Target Protein IL-10
Clonality Monoclonal
Storage/Stability -20°C/1 year
Application WB,ELISA
Recommended Dilution Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Concentration 1 mg/ml
Reactive Species Human
Host Species Mouse
Immunogen Purified recombinant fragment of human IL-10 expressed in E. Coli.
Specificity IL-10 Monoclonal Antibody detects endogenous levels of IL-10 protein.
Purification Affinity purification
Form Purified antibody in PBS containing 0.03% sodium azide.
Gene Name IL10
Accession No. P22301 P18893
Alternate Names IL10; Interleukin-10; IL-10; Cytokine synthesis inhibitory factor; CSIF
Description interleukin 10(IL10) Homo sapiens The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.[provided by RefSeq, May 2011],
Cell Pathway/ Category Cytokine-cytokine receptor interaction,Jak_STAT,T_Cell_Receptor,Intestinal immune network for IgA production,Asthma,Autoimmune thyroid disease,Systemic lupus erythematosus,Allograft rejection,
Protein Expression PCR rescued clones,Placenta,T-cell,
Subcellular Localization extracellular region,extracellular space,cytoplasm,
Protein Function disease:Defects in IL10 are a cause of susceptibility to Crohn disease (CD) [MIM:266600]. CD is a form of remitting inflammatory bowel disease (IBD). CD may involve any part of the gastrointestinal tract, but most frequently the terminal ileum and colon. Bowel inflammation is transmural and discontinuous. Crohn disease is commonly classified as autoimmune disease.,function:Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells.,online information:Interleukin-10 entry,online information:The Singapore human mutation and polymorphism database,similarity:Belongs to the IL-10 family.,subunit:Homodimer.,tissue specificity:Produced by a variety of cell lines, including T-cells, macrophages, mast cells and other cell types.,
Usage For Research Use Only! Not for diagnostic or therapeutic procedures.
Material Safety Data Sheet
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