ITM0366
ITM0366
- Catalog: ITM0366
- Gene/Protein: IL11
- Product Description: Immunotag™ IL-11 Monoclonal Antibody
504.0000
Price in reward points: 504
| Antibody Specification | |
| Datasheet | 
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| Target Protein | IL-11 |
| Clonality | Monoclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Mouse |
| Immunogen | Purified recombinant fragment of human IL-11 expressed in E. Coli. |
| Specificity | IL-11 Monoclonal Antibody detects endogenous levels of IL-11 protein. |
| Purification | Affinity purification |
| Form | Purified antibody in PBS containing 0.03% sodium azide. |
| Gene Name | IL11 |
| Accession No. | P20809 P47873 |
| Alternate Names | IL11; Interleukin-11; IL-11; Adipogenesis inhibitory factor; AGIF; Oprelvekin |
| Description | interleukin 11(IL11) Homo sapiens The protein encoded by this gene is a member of the gp130 family of cytokines. These cytokines drive the assembly of multisubunit receptor complexes, all of which contain at least one molecule of the transmembrane signaling receptor IL6ST (gp130). This cytokine is shown to stimulate the T-cell-dependent development of immunoglobulin-producing B cells. It is also found to support the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jun 2012], |
| Cell Pathway/ Category | Cytokine-cytokine receptor interaction,Jak_STAT,Hematopoietic cell lineage, |
| Protein Expression | Bone marrow,Prostate, |
| Subcellular Localization | extracellular region,extracellular space,cytoplasm, |
| Protein Function | function:Directly stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production.,online information:Clinical information on Neumega,online information:Interleukin-11 entry,pharmaceutical:Available under the name Neumega (Wyeth). Used for the prevention of severe thrombocytopenia and the reduction of the need for platelet transfusion following myelosuppressive chemotherapy.,similarity:Belongs to the IL-6 superfamily., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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