ITM0369
ITM0369
- Catalog: ITM0369
- Gene/Protein: IL1B
- Product Description: Immunotag™ IL-1β Monoclonal Antibody
504.0000
Price in reward points: 504
| Antibody Specification | |
| Datasheet | 
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| Target Protein | IL-1β |
| Clonality | Monoclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IHC-p,IF,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/200 - 1/1000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Mouse |
| Immunogen | Purified recombinant fragment of human IL-1β expressed in E. Coli. |
| Specificity | IL-1β Monoclonal Antibody detects endogenous levels of IL-1β protein. |
| Purification | Affinity purification |
| Form | Ascitic fluid containing 0.03% sodium azide. |
| Gene Name | IL1B |
| Accession No. | P01584 P10749 |
| Alternate Names | IL1B; IL1F2; Interleukin-1 beta; IL-1 beta; Catabolin |
| Description | interleukin 1 beta(IL1B) Homo sapiens The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. [provided by RefSeq, Jul 2008], |
| Cell Pathway/ Category | MAPK_ERK_Growth,MAPK_G_Protein,Cytokine-cytokine receptor interaction,Apoptosis_Inhibition,Apoptosis_Mitochondrial,Apoptosis_Overview,Toll_Like,NOD-like receptor,Cytosolic DNA-sensing pathway,Hematopoietic cell lineage,Type I diabetes mellitus,Alzheimer's disease,Prion diseases,Graft-versus-host disease, |
| Protein Expression | Histiocytic lymphoma,Leukocyte,Lung,Monocyte,Skin, |
| Subcellular Localization | extracellular region,extracellular space,lysosome,autophagosome,cytosol,secretory granule,extracellular exosome, |
| Protein Function | domain:The similarity among the IL-1 precursors suggests that the amino ends of these proteins serve some as yet undefined function.,function:Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.,online information:Interleukin-1 entry,online information:The Singapore human mutation and polymorphism database,similarity:Belongs to the IL-1 family.,subcellular location:The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins.,subunit:Monomer., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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