ITM0431
ITM0431
- Catalog: ITM0431
- Gene/Protein: CCL2
- Product Description: Immunotag™ MCP-1 Monoclonal Antibody
504.0000
Price in reward points: 504
| Antibody Specification | |
| Datasheet | 
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| Target Protein | MCP-1 |
| Clonality | Monoclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Mouse |
| Immunogen | Purified recombinant fragment of human MCP-1 expressed in E. Coli. |
| Specificity | MCP-1 Monoclonal Antibody detects endogenous levels of MCP-1 protein. |
| Purification | Affinity purification |
| Form | Purified antibody in PBS containing 0.03% sodium azide. |
| Gene Name | CCL2 |
| Accession No. | P13500 P10148 |
| Alternate Names | CCL2; MCP1; SCYA2; C-C motif chemokine 2; HC11; Monocyte chemoattractant protein 1; Monocyte chemotactic and activating factor; MCAF; Monocyte chemotactic protein 1; MCP-1; Monocyte secretory protein JE; Small-inducible cytokine A2 |
| Description | C-C motif chemokine ligand 2(CCL2) Homo sapiens This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Chemokines are a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of N-terminal cysteine residues of the mature peptide. This chemokine is a member of the CC subfamily which is characterized by two adjacent cysteine residues. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4. [provided by RefSeq, Jul 2013], |
| Cell Pathway/ Category | Cytokine-cytokine receptor interaction,Chemokine,NOD-like receptor, |
| Protein Expression | Glial tumor,Pancreas,Placenta, |
| Subcellular Localization | extracellular region,extracellular space,intracellular,rough endoplasmic reticulum,endocytic vesicle,dendrite,perikaryon,axon terminus,C-fiber,synapse,perinuclear region of cytoplasm, |
| Protein Function | function:Chemotactic factor that attracts monocytes and basophils but not neutrophils or eosinophils. Augments monocyte anti-tumor activity. Has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis or atherosclerosis. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis.,online information:CCL2 entry,polymorphism:Genetic variations in CCL2 determine Mycobacterium tuberculosis susceptibility [MIM:607948].,PTM:Processing at the N-terminus can regulate receptor and target cell selectivity. Deletion of the N-terminal residue converts it from an activator of basophil to an eosinophil chemoattractant.,similarity:Belongs to the intercrine beta (chemokine CC) family.,subunit:Monomer or homodimer; in equilibrium. Binds to CCR2 and CCR4. Is tethered on endothelial cells by glycosaminoglycan (GAG) side chains of proteoglycans., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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