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ITM0449

  • Gene/Protein: MPO
  • Product Description: Immunotag™ MPO Monoclonal Antibody
  • 368.0000
    Price in reward points: 368

    Available Options

ITM0449

Immunotag™ MPO Monoclonal Antibody
Antibody Specification
Datasheet
Target Protein MPO
Clonality Monoclonal
Storage/Stability -20°C/1 year
Application WB,ELISA
Recommended Dilution Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Concentration 1 mg/ml
Reactive Species Human
Host Species Mouse
Immunogen Purified recombinant fragment of MPO (aa1-193) expressed in E. Coli.
Specificity MPO Monoclonal Antibody detects endogenous levels of MPO protein.
Purification Affinity purification
Form Ascitic fluid containing 0.03% sodium azide.
Gene Name MPO
Accession No. P05164 P11247
Alternate Names MPO; Myeloperoxidase; MPO
Description myeloperoxidase(MPO) Homo sapiens Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor, myeloperoxidase is subsequently cleaved into a light and heavy chain. The mature myeloperoxidase is a tetramer composed of 2 light chains and 2 heavy chains. This enzyme produces hypohalous acids central to the microbicidal activity of neutrophils. [provided by RefSeq, Nov 2014],
Protein Expression Leukemia,Leukocyte,Liver,Plasma,Saliva,
Subcellular Localization extracellular space,nucleus,mitochondrion,lysosome,secretory granule,azurophil granule,extracellular exosome,
Protein Function catalytic activity:Cl(-) + H(2)O(2) = HOCl + 2 H(2)O.,catalytic activity:Donor + H(2)O(2) = oxidized donor + 2 H(2)O.,cofactor:Binds 1 calcium ion per heterodimer.,cofactor:Binds 1 heme B (iron-protoporphyrin IX) group covalently per heterodimer.,disease:Defects in MPO are the cause of myeloperoxidase deficiency (MPD) [MIM:254600]. MPD is an autosomal recessive defect that results in disseminated candidiasis.,function:Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity.,online information:MPO mutation db,online information:Myeloperoxidase entry,similarity:Belongs to the peroxidase family. XPO subfamily.,subunit:Tetramer of two light chains and two heavy chains.,
Usage For Research Use Only! Not for diagnostic or therapeutic procedures.
Material Safety Data Sheet
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